兰州大学机构库 >药学院
Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal
Wang, Pengpeng1; Liu, Huapeng1; Zhao, QY(赵全义)1; Chen, Yonglin2; Liu, B(刘斌)3; Zhang, BP(张宝平)3; Zheng, Qian3
2014-03-03
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN0223-5234
Volume74Pages:199-215
AbstractIn this paper, drug-like properties of two series of carbonyl metal CO-releasing molecules, Ru(CO)(3)ClnL (n = 1, L = amino acid or its derivatives 1-7, L=acetylacetone 8 or 2,2 '-bipyridyl 9; n = 2, L=aminopyridine derivatives 10-13; n = 0, L=salicylaldehyde Schiff base 14-15) and M(CO)(5)L(M = Cr, Mo, W; L = glycine methyl ester 16-18; L=N-methyl imidazole 19-21), were preliminarily evaluated from four aspects involving in cytotoxicity, in vivo toxicity, bio-distribution and metabolism. Cytotoxic effects of all complexes were assayed by mu. IC50 values of complexes 1-15 were 39.55-240.16 mg/l, and those of complexes 16 and 18 were 21.36-22.21 mg/l. Toxicity tests of mice used oral acute toxic class method and got LD50 values of some complexes; among them, LD50 of complex 1 was in 800-1000 mg/kg, complex 7 in 1100-1500 mg/kg and complex 18 in 75-125 mg/kg. After several consecutive administrations, tested complexes severely damaged liver and kidney in both functional and morphological aspects. And by metal ions measurements using ICP-AES, we found that the tested complexes were unevenly distributed in tissues and organs. In vivo, Ru-II in complexes was oxidized to Ru-III by P450 enzymes, and for Mo-0 and W-0 in complexes, part of them transformed into higher oxidation state, the others kept original state. (C) 2014 Elsevier Masson SAS. All rights reserved.
KeywordCO-releasing molecules Toxicity Distribution Metabolism Drug-like properties
Subject AreaPharmacology & Pharmacy
PublisherELSEVIER
DOI10.1016/j.ejmech.2013.12.041
Publication PlacePARIS
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 甘肃省自然科学基金计划
Project NumberNational Natural Science Foundations of China [21171079] ; Natural Science Foundations of Gansu province [1107RJZA264]
WOS IDWOS:000333780800019
Funding OrganizationNSFC ; GSSTD
SubtypeArticle
PMID 24463436
BIOSIS IDBIOSIS:PREV201400413859
Department[Wang, Pengpeng;
Liu, Huapeng;
Zhao, Quanyi] Lanzhou Univ, Sch Pharm, Inst Med Chem, Lanzhou 730000, Peoples R China;
[Chen, Yonglin] Lanzhou Univ, Affiliated Hosp 1, Lanzhou 730000, Peoples R China;
[Liu, Bin;
Zhang, Baoping;
Zheng, Qian] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
Citation statistics
Cited Times:48[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/122003
Collection药学院
口腔医学院
第一临床医学院
Corresponding AuthorZhao, Quanyi
Affiliation
1.Lanzhou Univ, Sch Pharm, Inst Med Chem, Lanzhou 730000, Peoples R China
2.Lanzhou Univ, Affiliated Hosp 1, Lanzhou 730000, Peoples R China
3.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
First Author AffilicationSchool of Pharmacy
Corresponding Author AffilicationSchool of Pharmacy
First Signature AffilicationSchool of Pharmacy
Recommended Citation
GB/T 7714
Wang, Pengpeng,Liu, Huapeng,Zhao, Quanyi,et al. Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2014,74:199-215.
APA Wang, Pengpeng.,Liu, Huapeng.,Zhao, Quanyi.,Chen, Yonglin.,Liu, Bin.,...&Zheng, Qian.(2014).Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,74,199-215.
MLA Wang, Pengpeng,et al."Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 74(2014):199-215.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Wang, Pengpeng]'s Articles
[Liu, Huapeng]'s Articles
[Zhao, Quanyi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Pengpeng]'s Articles
[Liu, Huapeng]'s Articles
[Zhao, Quanyi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Pengpeng]'s Articles
[Liu, Huapeng]'s Articles
[Zhao, Quanyi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Syntheses and evaluation of drug-like properti.pdf
Format: Adobe PDF
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.