兰州大学机构库 >第一临床医学院
Helicobacter pylori-induced gastric inflammation and gastric cancer
Wang, F; Meng, WB; Wang, BY; Qiao, L; Wang, BY (reprint author), China Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Shenyang 110001, Liaoning Provin, Peoples R China.
ESI NOTE2017-07-19;Highly Cited Papers
2014-04-10
Source PublicationCANCER LETTERS
ISSN0304-3835
Volume345Issue:2Pages:196-202
AbstractHelicobacter pylori (H. pylori) infect over half of the world's population. The prevalence of H. pylori infection and the predominant genotype of H. pylori virulence factors vary considerably across different geographical regions. H. pylori could uniquely persist for decades in the harsh stomach environment, where it damages the gastric mucosa and changes the pattern of gastric hormone release, thereby affects gastric physiology. By utilizing various virulence factors, H. pylori targets different cellular proteins to modulate the host inflammatory response and initiate multiple "hits" on the gastric mucosa, resulting in chronic gastritis and peptic ulceration. Among the long-term consequences of H. pylori infection is gastric malignancies, particularly gastric cancer (GC) and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. As such, H. pylori has been recognized as a class I carcinogen by the International Agency for Research on Cancer. Despite a close causal link between H. pylori infection and the development of gastric malignancies, the precise mechanisms involved in this process are still obscure. Studies over the past two decades have revealed that H. pylori exert oncogenic effects on gastric mucosa through a complex interaction between bacterial factors, host factors, and environmental factors. Numerous signaling pathways can be activated by H. pylori. In this review, we aim to elaborate on the recent developments in the pathophysiological mechanisms of H. pylori-induced gastric inflammation and gastric cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
KeywordCagA VacA Epigenetic changes Gastric cancer Helicobacter pylori
Subject AreaOncology
PublisherELSEVIER
DOI10.1016/j.canlet.2013.08.016
Publication PlaceCLARE
Indexed BySCIE ; PubMed ; MEDLINE ; ESI
Language英语
First Inst
WOS IDWOS:000334000000009
SubtypeReview
PMID 23981572
Department[Wang, Fei] Guangxi Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanning 530021, Guangxi Provinc, Peoples R China;
[Meng, Wenbo] Lanzhou Univ, Dept Gen Surg 2, Hepatopancreatobiliary Surg Inst Gansu Prov, Clin Med Coll Canc,Ctr Lanzhou Univ,Hosp 1, Lanzhou 730000, Gansu, Peoples R China;
[Wang, Bingyuan] China Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Shenyang 110001, Liaoning Provin, Peoples R China;
[Qiao, Liang] Westmead Hosp, Univ Sydney, Westmead Millennium Inst, Storr Liver Unit, Westmead, NSW 2145, Australia
Citation statistics
Cited Times:332[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/125845
Collection第一临床医学院
Corresponding AuthorWang, BY (reprint author), China Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Shenyang 110001, Liaoning Provin, Peoples R China.
Recommended Citation
GB/T 7714
Wang, F,Meng, WB,Wang, BY,et al. Helicobacter pylori-induced gastric inflammation and gastric cancer[J]. CANCER LETTERS,2014,345(2):196-202.
APA Wang, F,Meng, WB,Wang, BY,Qiao, L,&Wang, BY .(2014).Helicobacter pylori-induced gastric inflammation and gastric cancer.CANCER LETTERS,345(2),196-202.
MLA Wang, F,et al."Helicobacter pylori-induced gastric inflammation and gastric cancer".CANCER LETTERS 345.2(2014):196-202.
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