兰州大学机构库 >第一临床医学院
环氧合酶2和尿纤溶酶原激活物在胃癌中的表达及其临床意义
Alternative TitleExpression of cyclooxygenase-2 and urokinase plasminogen activator in gastric carcinoma and the clinical significance thereof
张富花; 周永宁; 李高忠; 李强; 陆斌; 张志镒; 吴正奇; 樊平; 郝天军
2008
Source Publication中华医学杂志   Impact Factor & Quartile
ISSN0376-2491
Volume88Issue:46Pages:3279-3282
Abstract目的 研究环氧合酶(COX)-2和尿激酶型纤溶酶原激活物(uPA)在胃癌中的表达,分析其与临床病理特征及生存期的关系.方法 用绀织芯片技术和免疫组化法检测甘肃省武威地区192例胃痛组织、56例癌旁组织中COX-2、uPA的表达,免疫组化双染测微血管密度(MVD)和微淋巴管密度(MLD).取30例当地同期胃镜检查的正常胃黏膜标本作为对照.结果 COX-2在胃痛和癌旁组的阴性率(67.7%和62.5%)均显著高于对照组(40%,P<0.05),且与浸润深度和MVD有关(均P<0.05).uPA在胃癌、癌旁和对
Other AbstractOBJECTIVE: To investigate expression of cyclooxygenase-2 (COX-2) and urokinase plasminogen activator (uPA) in gastric carcinoma and the clinical significance thereof.METHODS: Strepavidin-peroxidase method was used to detect the expression of COX-2 and uPA in 192 specimens of gastric carcinoma, 56 specimens of paracancer tissues obtained during operation. Immunohistochemical double staining was used to detect the microvessel density (MVD) and microlymphatic density (MLD). Thirty specimens of normal gastric mucosa obtained during gastroscopy were used as controls.RESULTS: The positive rates of COX-2 in the gastric carcinoma and paracancer tissues were 67.7% and 62.5% respectively, both significantly higher than that of the control group (40.0%, both P < 0.05). The positive expression of COX-2 in gastric carcinoma was significantly related with the depth of invasion and MVD (both P < 0.05). The positive rates of uPA in the gastric carcinoma, paracancer tissue were 78.1% and 44.6% respectively, both significantly higher than that of the control tissues (6.7%, both P < 0.01) and there was a significant difference in the positive rates of uPA between the first 2 groups too (P < 0.01). The positive expression of uPA in gastric carcinoma was significantly related with lymph node metastasis, depth of invasion, Lauren typing, differentiation, MVD, and MLD (P < 0.05, P < 0.01). COX-2 expression was positively linked with uPA expression (r = 0.167, P = 0.021). The survival time of the uPA positive group was (38 +/- 4) months, significantly shorter than that of the negative group [(54 +/- 6) months, P < 0.05]. The survival time of the group positive in both COX-2 and uPA was (27 +/- 3) months, significantly shorter than that of the single positive or double negative groups [both (58 +/- 4) months, both P < 0.01).CONCLUSION: COX-2 and uPA are highly expressed in gastric carcinoma. COX-2 expression is positively linked with uPA expression. COX-2 and uPA in the gastric carcinoma participate in the development of gastric cancer in the early process. uPA is significantly related with the survival time.
Keyword胃肿瘤 环氧化酶2 尿纤溶酶原激活物 病理学,临床
Subject AreaGeriatrics & Gerontology ; Biochemistry & Molecular Biology ; Gastroenterology & Hepatology ; Genetics & Heredity ; Oncology
Publication PlaceBEIJING
Indexed ByPubMed ; MEDLINE ; CSCD
Language中文
First Inst
Funding Project国家自然科学基金项目 ; 甘肃省科学事业费项目计划
Host of Journal中华医学会
Project Number国家自然科学基金资助项目(30872478) ; 甘肃省科学事业费基金资助项目(QS051-C33-10)
CSCD IDCSCD:3477787
Funding OrganizationNSFC ; GSSTD
PMID 19159555
IRIDCSCD:0000425
Department甘肃省第一人民医院消化科;
兰州大学第一医院消化科
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/167016
Collection第一临床医学院
Recommended Citation
GB/T 7714
张富花,周永宁,李高忠,等. 环氧合酶2和尿纤溶酶原激活物在胃癌中的表达及其临床意义[J]. 中华医学杂志,2008,88(46):3279-3282.
APA 张富花.,周永宁.,李高忠.,李强.,陆斌.,...&郝天军.(2008).环氧合酶2和尿纤溶酶原激活物在胃癌中的表达及其临床意义.中华医学杂志,88(46),3279-3282.
MLA 张富花,et al."环氧合酶2和尿纤溶酶原激活物在胃癌中的表达及其临床意义".中华医学杂志 88.46(2008):3279-3282.
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