兰州大学机构库 >第一临床医学院
塞来昔布诱导人胃癌细胞凋亡抑制新生血管形成
Alternative TitleCelecoxib induces apoptosis and inhibits angiogenesis in gastric cancer
冉俊涛; 周永宁; 唐承薇; 陆建荣; 吴静; 路红; 杨国栋
2008
Source Publication中华肿瘤杂志   Impact Factor & Quartile
ISSN0253-3766
Volume30Issue:6Pages:448-451
Abstract目的 探讨环氧合酶2(COX-2)抑制剂塞来昔布对人胃癌细胞增殖和新生血管形成的抑制作用.方法 将59例胃癌患者随机分为试验组(37例)和对照组(22例),试验组术前给予常规剂量塞来昔布,共7d,然后行手术治疗;对照组行单纯手术治疗.免疫组化法检测胃癌组织中COX-2和血管内皮生长因子(VEGF)的表达及微血管密度(MVD),DNA末端原位标记染色法检测胃癌细胞凋亡.以20例健康人作为正常对照.结果 试验组胃癌细胞凋亡率为7.1%±1.0%,显著高于对照组(6.2%±0.9%,P<0.05).试验组和对照
Other AbstractOBJECTIVE: The aim of this study was to explore the effect of celecoxib, a cyclooxygenase-2 inhibitor, on induction of apoptosis and inhibition of angiogenesis in gastric cancer.METHODS: Fifty nine gastric cancer patients were randomly divided into 2 groups: celecoxib group (n = 37) and control group (n = 22). The patients in the celecoxib group were treated orally with celecoxib 200 mg twice daily for 7 days before resection. The patients in the control group received surgical resection alone. Another group of 20 healthy subjects were recruited as normal control. The number of apoptotic tumor cells was measured by terminal deoxynucleotidyl transferse-mediated dUTP nick end labeling (TUNEL). The expression of COX-2, VEGF and the microvessel density (MVD) were evaluated by immunohistochemistry.RESULTS: The TUNEL results showed an increase of apoptosis in the tumor cells after celecoxib treatment in comparison with that in the control group (7.1% +/- 1.0% vs. 6.2% +/- 0.9%, P < 0.05). The expression level of COX-2 and VEGF in the gastric cancer tissues was significantly decreased in the celecoxib group compared with those in the control group (P < 0.05). Furthermore, MVD was also significantly lower in the celecoxib group when compared with that in the control group (30.48 +/- 5.02 vs. 38.98 +/- 4.58, P < 0.05).CONCLUSION: Oral intake of celecoxib can induce apoptosis and suppress angiogenesis in gastric cancer. It may become an effective agent in the treatment of gastric cancer.
Keyword塞来昔布 胃肿瘤 凋亡 新生血管形成
Subject AreaOncology ; Geriatrics & Gerontology ; Cell Biology ; Pharmacology & Pharmacy ; Biochemistry & Molecular Biology ; Cardiovascular System & Cardiology ; Pathology
Publication PlaceBEIJING
Indexed ByPubMed ; MEDLINE ; CSCD
Language中文
First Inst
Funding Project甘肃省科技攻关计划项目
Host of Journal中华医学会
Project Number甘肃省科技攻关项目(2GS042-A43-014-18)
CSCD IDCSCD:3366015
Funding OrganizationGSSTD
PMID 19024521
IRIDCSCD:0000432
Department兰州大学第一医院消化科;
四川大学华西医院消化科;
第四军医大学病理教研室
Citation statistics
Cited Times:3[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/167244
Collection第一临床医学院
Recommended Citation
GB/T 7714
冉俊涛,周永宁,唐承薇,等. 塞来昔布诱导人胃癌细胞凋亡抑制新生血管形成[J]. 中华肿瘤杂志,2008,30(6):448-451.
APA 冉俊涛.,周永宁.,唐承薇.,陆建荣.,吴静.,...&杨国栋.(2008).塞来昔布诱导人胃癌细胞凋亡抑制新生血管形成.中华肿瘤杂志,30(6),448-451.
MLA 冉俊涛,et al."塞来昔布诱导人胃癌细胞凋亡抑制新生血管形成".中华肿瘤杂志 30.6(2008):448-451.
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