兰州大学机构库 >第一临床医学院
胃癌组织中Ets-1的表达及其与血管生成临床病理特征和预后的关系
Alternative TitleRelationship between Ets-1 expression and angiogenesis, clinicopathological features and survival of patients with gastric carcinoma
任涛文; 周永宁; 吴静; 张志镒; 郝天军; 王娟霞; 邹绍静; 陈兆峰; 黄珊珊; 张俐花; 赵越
2009
Source Publication中华肿瘤杂志   Impact Factor & Quartile
ISSN0253-3766
Volume31Issue:9Pages:674-678
Abstract目的 探讨胃癌组织、癌旁组织及淋巴结转移灶中Ets-1表达的临床意义,分析Ets-1表达与血管生成、临床病理特征及预后的关系.方法 应用免疫组化SP法,采用组织芯片技术,检测189例胃癌组织、54例癌旁组织、41例淋巴结转移灶及32例正常胃黏膜中Ets-1蛋白的表达.对胃癌患者通过上门或电话进行问卷随访.结果 胃癌组织、癌旁组织和正常胃黏膜Ets-1的阳性表达率分别为71.4%、29.6%和18.8%,3组间差异有统计学意义(P<0.01).135例Ets-1表达阳性的胃癌组织微血管密度(MVD)为30.
Other AbstractOBJECTIVE: To investigate the expression of Ets-1 in gastric carcinoma, para-cancerous tissue and metastatic lymph nodes, and to determine the relationship between Ets-1 expression and clinicopathological features, angiogenesis and survival of patients with gastric carcinoma.METHODS: Gastric carcinoma tissue microarray was used to determine Ets-1 protein expression by SP immunohistochemical staining in 189 advanced gastric cancer, 54 papacancerous tissues, 41 metastatic lymph nodes and 32 control tissues.RESULTS: The positive rates for Ets-1 expression of the carcinoma, paracancerous and control tissues were 71.4%, 29.6% and 18.8%, respectively, with a significant difference among the three groups (P < 0.01). In the cancer tissues, the positive rate of Ets-1 protein expression was significantly associated with depth of invasion and lymph node metastasis (P < 0.01), but not associated with degree of differentiation, Lauren's histological type, sex, age, and size of tumor (P > 0.05). The positive rates for Ets-1 expression of the 41 gastric cancer and 41 metastatic lymph nodes were significantly different (P < 0.05). In metastatic lymph nodes, the positive rate for Ets-1 expression was higher. The MVD in Ets-1 positive tumors was higher than that in the Ets-1 negative tumors, with a significant difference (P < 0.05). Kaplan-Meier survival analysis showed that the survival time of Ets-1-negative patients was longer than that of Ets-1-positive patients (P < 0.05). Cox regression analysis showed that Ets-1 expression was not an independent prognostic factor of gastric carcinoma.CONCLUSION: A higher expression of Ets-1 is involved in carcinogenesis, development, invasion, and metastasis of gastric cancer. Ets-1 plays an important role in angiogenesis in gastric cancer. Ets-1 is a useful marker for predicting the outcome for patients with gastric carcinoma, though it is not an independent prognostic indicator.
Keyword胃肿瘤 Ets-1 微血管密度 临床病理特征 预后
Subject AreaGeriatrics & Gerontology ; Oncology ; Cardiovascular System & Cardiology ; Pathology ; Microscopy ; Mathematics ; Biochemistry & Molecular Biology ; Demography
Publication PlaceBEIJING
Indexed ByPubMed ; MEDLINE ; CSCD
Language中文
First Inst
Funding Project国家自然科学基金项目
Host of Journal中华医学会
Project Number国家自然科学基金
CSCD IDCSCD:3670486
Funding OrganizationNSFC
PMID 20021863
IRIDCSCD:0000501
Department兰州大学第一医院,消化内科;
甘肃省武威市肿瘤医院,消化内科
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/167468
Collection第一临床医学院
Recommended Citation
GB/T 7714
任涛文,周永宁,吴静,等. 胃癌组织中Ets-1的表达及其与血管生成临床病理特征和预后的关系[J]. 中华肿瘤杂志,2009,31(9):674-678.
APA 任涛文.,周永宁.,吴静.,张志镒.,郝天军.,...&赵越.(2009).胃癌组织中Ets-1的表达及其与血管生成临床病理特征和预后的关系.中华肿瘤杂志,31(9),674-678.
MLA 任涛文,et al."胃癌组织中Ets-1的表达及其与血管生成临床病理特征和预后的关系".中华肿瘤杂志 31.9(2009):674-678.
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