兰州大学机构库 >第一临床医学院
超声光散射断层成像(DOT)与乳腺癌血管生成病理学的相关性
Alternative TitleCorrelation between diffused optical tomography (DOT) with ultrasonography location and pathology of angiogenesis in breast cancer
王红磊; 武力; 阙燕; 马大昌; 吴多明
2012-05-15
Source Publication复旦学报(医学版)   Impact Factor & Quartile
ISSN1672-8467
Volume39Issue:3Pages:261-267
Abstract目的通过研究乳腺癌超声光散射断层成像(diffused optical tomography,DOT)综合诊断指数(synthesis diagnostic index,SDI)以及CD105、血管内皮生长因子(vascular endothelial growth factor,VEGF)、缺氧诱导因子-1α(hypoxia inducible factor-lα,HIF-1α)在乳腺癌中的表达,探讨乳腺癌超声DOT-SDI与微血管密度(microvessel density,MVD)、VEGF和HIF-1α表达的关系。方法采用超声DOT系统,研究163例乳腺良性病变(含典型良性病变108例...
Other AbstractObjective To investigate the correlation between synthesis diagnostic index (SDI) of diffused optical tomography (DOT) with ultrasonography (US) localization and microvessel density (MVD) based on CD105, as well as the vascular endothelial growth factor (VEGF) and HIF-1 alpha expression in breast cancer. Methods SDI were demonstrated by DOT with US location for 163 patients with benign mass (which include 108 cases of typical breast benign lesions,31 cases of intraductal papillomatosis and 24 cases of atypia ductal hyperplasia), and for 167 patients with breast cancer (37 cases of ductal carcinoma in situ and 130 cases of invasive breast cancer). The receiver operating characteristic (ROC) curve analysis was used to estimate the optimal diagnostic threshold of breast cancer. The MVD based on CD105 and the expressions of VEGF and HIF-1 alpha were detected by immunohistochemistry on all the 167 cases of breast cancer. Correlation between SDI,MVD and the expressions of VEGF and HIF-1 alpha in breast cancer was analyzed. Results ROC curve analysis showed that the SDI value was 0.879 under the area of ROC curve. The SDI value >140.81 was used as the optimal diagnostic threshold of breast cancer. The mean SDI values were 83.46 +/- 37.47 for typical breast benign lesions cases, 130.46 +/- 59.24 for intraductal papillomatosis cases, 142.14 +/- 64.33 for atypia ductal hyperplasia cases, 157.81 +/- 31.86 for ductal carcinoma in situ cases and 190.43 +/- 61.60 for invasive breast cancer cases. The mean SDI values were significantly different between typical breast benign lesions and all other groups, as well as the invasive breast cancers (P<0.05). There was no statistical difference between intraductal papilloma, mammary dysplasia and invasive breast cancer(P>0.05). The SDI value has linear correlation with MVD of breast cancer (P<0.05). The SDI and MVD values were positively correlated with the VEGF and HIF-1 alpha expression in breast cancer. Conclusions SDI-DOT with us is closely related to microvessel density as well as the expressions of VEGF and HIF-1 alpha in breast cancer, which can indirectly reflect the angiogenic activity and tissue hypoxia. It also might play a great role in early diagnosis and in distinguishing benign vs. malignant tumors.
Keyword超声光散射成像系统(DOT) 综合诊断指数(SDI) 微血管密度(MVD) 血管内皮生长因子(VEGF) 缺氧诱导因子-1α(HIF-1α) 乳腺癌
Subject AreaBiochemistry & Molecular Biology ; Radiology, Nuclear Medicine & Medical Imaging ; Oncology ; Obstetrics & Gynecology
DOI10.3969/j.issn.1672-8467.2012.03.008
Publication PlaceSHANGHAI
Indexed ByBIOSIS ; CSCD
Language中文
First Inst
Host of Journal复旦大学
CSCD IDCSCD:4549161
SubtypeArticle
BIOSIS IDBIOSIS:PREV201200623682
IRIDCNKI:0053158
Department兰州大学第一医院乳腺科
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/168746
Collection第一临床医学院
Recommended Citation
GB/T 7714
王红磊,武力,阙燕,等. 超声光散射断层成像(DOT)与乳腺癌血管生成病理学的相关性[J]. 复旦学报(医学版),2012,39(3):261-267.
APA 王红磊,武力,阙燕,马大昌,&吴多明.(2012).超声光散射断层成像(DOT)与乳腺癌血管生成病理学的相关性.复旦学报(医学版),39(3),261-267.
MLA 王红磊,et al."超声光散射断层成像(DOT)与乳腺癌血管生成病理学的相关性".复旦学报(医学版) 39.3(2012):261-267.
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