兰州大学机构库 >第二临床医学院
白细胞介素6受体基因单核苷酸多态性与2型糖尿病的关联性
Alternative TitleAssociation study of single nucleotide polymorphism of interleukin 6 receptor gene and type 2 diabetes in Chinese Han population
张明; 田林红
2006-12-10
Source Publication中华医学遗传学杂志   Impact Factor & Quartile
ISSN1003-9406
Volume23Issue:6Pages:662-664
Abstract目的探讨甘肃地区汉族人中白细胞介素6受体基因(interleukin6receptorgene,IL6R)启动子-183(G→A)和第9外显子D358A的变异与2型糖尿病(type2diabetesmellitus,T2DM)的关联。方法随机选取无亲缘关系甘肃地区汉族人183名,其中T2DM患者87例、正常对照96名,应用聚合酶链反应-限制性片段长度多态性(polymerasechainreaction-restrictionfragmentlengthpolymorphism,PCR-RFLP)方法进行-183(G→A)和D358A变异的检测。结果正常对照组D358A的3种基因型频率和等位基...
Other AbstractOBJECTIVE: To determine the association of the promoter and exon 9 of interleukin 6 receptor gene IL6R and the susceptibility of type 2 diabetes mellitus in Chinese Han population.METHODS: A total of 183 unrelated subjects, including 87 type 2 diabetes and 96 normal glucose tolerant (NGT) controls, were recruited. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were employed to screen the polymorphism.RESULTS: In the normal glucose tolerant control group, the genotype frequencies and allele frequencies of D358A were AA 31.2%, AC 41.7%, CC 27.1%, A 52.1%, C 47.9%, while the corresponding frequencies in the type 2 diabetes group were AA 44.8%, AC 41.4%, CC 13.8%, A 65.5%, C 34.5% respectively, the CC genotype frequency and C allele frequency of normal glucose tolerant control was higher than that of type 2 diabetes (Chi2 test=4.900, P< 0.05; Chi2 test=6.784, P< 0.01). No differences were found in the genotype frequencies and allele frequencies of -183(G --> A).CONCLUSION: The above results suggest that the D358A polymorphism of IL6R maybe correlate with type 2 diabetes in Chinese Han population.
Keyword白细胞介素6受体基因 2型糖尿病 遗传多态性
Subject AreaGeriatrics & Gerontology ; Anthropology ; Genetics & Heredity ; Endocrinology & Metabolism ; Immunology
Publication PlaceCHENGDU
Indexed ByPubMed ; MEDLINE ; BIOSIS ; CSCD
Language中文
First Inst
Funding Project甘肃省科学事业费项目计划
Host of Journal中华医学会
Project Number甘肃省科学事业费研究项目基金(QS051-C33-15)~~
CSCD IDCSCD:2673571
Funding OrganizationGSSTD
PMID 17160948
BIOSIS IDBIOSIS:PREV200700084633
IRIDCNKI:0029794
Department兰州大学第二医院内分泌科;
兰州大学第二医院内分泌科
Citation statistics
Cited Times:3[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/172456
Collection第二临床医学院
Recommended Citation
GB/T 7714
张明,田林红. 白细胞介素6受体基因单核苷酸多态性与2型糖尿病的关联性[J]. 中华医学遗传学杂志,2006,23(6):662-664.
APA 张明,&田林红.(2006).白细胞介素6受体基因单核苷酸多态性与2型糖尿病的关联性.中华医学遗传学杂志,23(6),662-664.
MLA 张明,et al."白细胞介素6受体基因单核苷酸多态性与2型糖尿病的关联性".中华医学遗传学杂志 23.6(2006):662-664.
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