兰州大学机构库 >第二临床医学院
全国多中心类风湿关节炎冠心病危险因素的现况调查
Alternative TitleA multicenter study of coronary artery disease and its risk factors in rheumatoid arthritis in China
2012-04-18
Source Publication北京大学学报(医学版)   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN1671-167X
Volume44Issue:2Pages:176-181
Abstract目的:了解我国类风湿关节炎(rheumatoid arthritis,RA)患者冠心病(coronary artery disease,CAD)的患病情况并评估其发生的危险因素。方法:调查RA患者冠心病相关的临床资料,包括冠心病的患病情况、冠心病传统危险因素[糖尿病、高血压、高血脂、吸烟及体重指数(BMI)]及RA临床表现[关节肿胀、疼痛、畸形数目,皮下结节数目,动态红细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)、类风湿因子(rheumatoid factor,RF)等]、关节功能状态评分及用药情...
Other AbstractOBJECTIVE: To learn about the prevalence and risk factors of coronary artery disease (CAD) in rheumatoid arthritis (RA).METHODS: Data were obtained from a 12-month retrospective investigation of the patients with RA, randomly selected from Departments of Rheumatology and Immunology in 21 big hospitals in China. The data were collected about their social conditions, clinical conditions, medications associated with RA, such as disease modifying anti-rheumatic drugs (DMARDs), non steroidal anti-inflammatory drugs (NSAIDs), glucocorticoid, biologic agents. A nonparameter test and multivariate logistic regression analysis were performed.RESULTS: In the study, 960 patients were enrolled. The prevalence of CAD was 3.5% in China, which was obviously higher than that of normal people. The prevalence of overweight and obesity, smoking, hypertension, diabetes mellitus, hypercholesterolemia and cerebrovascular disease were 35.1%, 12.3%, 17.0%, 7.7%, 0.4% and 3.0%, respectively. Compared with the control group, the CAD group had higher age [(64.7±9.3) years vs. (52.3±14.0) years,P<0.001], more rheumatoid nodules (14.7% vs. 3.1%,P=0.005), lower rate of hydroxychloroquine (HCQ) use (5.9% vs. 22.6%,P=0.021), higher prevalence rates of lung interstitial disease (17.5% vs. 7.0%,P<0.001), diabetes mellitus and hypertension (29.4% vs. 7.0%,P<0.001; 38.2% vs. 16.2%,P=0.001). There was no obvious correlation of CAD in RA with joint deformity, rheumatoid factor (RF) titer, glucocorticoid use, hypercholesterolemia and body mass index (BMI). Multivariate analysis showed higher age, diabetes mellitus and hypertension were independent predictors of CAD, and the use of HCQ was a protective factor of CAD.CONCLUSION: The prevalence of CAD is 3.5%. Higher age, diabetes mellitus and hypertension are independent predictors of CAD, and the use of HCQ is a protective factor of CAD.
Keyword关节炎,类风湿 冠心病 危险因素 患病率
Subject AreaPediatrics ; Geriatrics & Gerontology ; Rheumatology ; Cardiovascular System & Cardiology ; Endocrinology & Metabolism ; Demography
Publication PlaceBEIJING
Indexed ByPubMed ; MEDLINE ; CSCD
Language中文
First Inst
Funding Project国家科技支撑计划
Host of Journal北京大学
Project Number“十一五”国家科技支撑计划项目(2008BAI59B01)资助~~
CSCD IDCSCD:4503644
Funding OrganizationMOST
PMID 22516983
IRIDCNKI:0050450
Department
北京大学人民医院风湿免疫科;
北京大学首钢医院多顶街社区卫生中心全科;
中国医学科学院北京协和医学院阜外心血管病医院心内科;
山西医科大学第二医院风湿免疫科;
包头医学院第一附属医院风湿免疫科;
中日友好医院风湿免疫科;
第四军医大学西京医院风湿免疫科;
河北医科大学第二医院风湿免疫科;
北京大学第三医院风湿免疫科;
河北医科大学第三医院风湿免疫科...更多
Citation statistics
Cited Times:11[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/174712
Collection第二临床医学院
Recommended Citation
GB/T 7714
李春,王秀茹,唐熠达,等. 全国多中心类风湿关节炎冠心病危险因素的现况调查[J]. 北京大学学报(医学版),2012,44(2):176-181.
APA 李春.,王秀茹.,唐熠达.,安媛.,周云杉.,...&栗占国.(2012).全国多中心类风湿关节炎冠心病危险因素的现况调查.北京大学学报(医学版),44(2),176-181.
MLA 李春,et al."全国多中心类风湿关节炎冠心病危险因素的现况调查".北京大学学报(医学版) 44.2(2012):176-181.
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