兰州大学机构库 >基础医学院
乙酰肝素酶mRNA表达与血管生成与胃癌发展的关系
Alternative TitleRelation of heparanase mRNA expression and angiogenesis to the progression of gastric carcinoma
任小龙; 朱任之; 王丽京; 张明立; 李东海; 邓肖群
2003-07-23
Source Publication中华肿瘤杂志   Impact Factor & Quartile
ISSN0253-3766
Volume25Issue:4Pages:368-371
Abstract目的 探讨乙酰肝素酶mRNA表达状况和血管生成与胃癌发展的关系。方法 应用原位杂交技术 ,检测 5 2例胃癌组织中乙酰肝素酶mRNA的表达情况 ,并用免疫组化法对全部标本用CD34抗体进行肿瘤血管内皮染色 ,计数肿瘤微血管密度 (MVD) ,分析乙酰肝素酶mRNA与MVD及其与胃癌组织分化程度、浸润深度、淋巴结转移和器官转移的关系。结果 胃癌组织乙酰肝素酶mRNA阳性表达 2 5例 (4 8.1% ) ,MVD平均值为 73.2± 2 2 .8;阴性表达 2 7例 (5 1.9% ) ,MVD平均值为 4 4 .8±11.9,两者之间差异有显著性 (P
Other AbstractOBJECTIVE: To investigate the relation of heparanase gene and angiogenesis with the progress of gastric carcinoma (GC).METHODS: Expression of heparanase mRNA in 52 GC tissue was detected by in situ hybridization assay. Microvessel density (MVD) was examined by immunohistochemical method. MVD and heparanase mRNA expression were analysed with their relation to histological grade, invasion depth,lymph node metastasis and organ metastasis.RESULTS: MVD was 73.2 +/- 22.8 in 25 (48.1%) tissue with positive heparanase mRNA. It was 44.8 +/- 11.9 in 27 (51.9%) tissues with negative heparanase mRNA, between which the difference was significant (P < 0.001). MVD and heparanase mRNA expression were related with lymph node metastasis and depth of serosal invasion in GC (P < 0.005).CONCLUSION: Heparanase, being related to angiogenesis in gastric cancer, promotes growth, invasion and metastasis. Heparanase mRNA expression is an important predictor of the biological behavior of human gastric carcinoma.
Keyword胃肿瘤 乙酰肝素酶 新生血管 肿瘤转移
Subject AreaOncology ; Geriatrics & Gerontology ; Gastroenterology & Hepatology ; Genetics & Heredity ; Biochemistry & Molecular Biology ; Cardiovascular System & Cardiology ; Pathology
Publication PlaceBEIJING
Indexed ByPubMed ; MEDLINE ; CSCD
Language中文
First Inst
Host of Journal中华医学会
CSCD IDCSCD:1325152
PMID 12921569
IRIDCNKI:0064145
Department兰州市第一人民医院兰州医学院附属兰州医院功能科;
兰州医学院病理学教研室;
兰州医学院病理学教研室;
兰州市第一人民医院兰州医学院附属兰州医院功能科;
兰州市第一人民医院兰州医学院附属兰州医院病理科;
兰州市第一人民医院兰州医学院附属兰州医院功能科 730050;
730050;
730050;
730050
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/177760
Collection基础医学院
Recommended Citation
GB/T 7714
任小龙,朱任之,王丽京,等. 乙酰肝素酶mRNA表达与血管生成与胃癌发展的关系[J]. 中华肿瘤杂志,2003,25(4):368-371.
APA 任小龙,朱任之,王丽京,张明立,李东海,&邓肖群.(2003).乙酰肝素酶mRNA表达与血管生成与胃癌发展的关系.中华肿瘤杂志,25(4),368-371.
MLA 任小龙,et al."乙酰肝素酶mRNA表达与血管生成与胃癌发展的关系".中华肿瘤杂志 25.4(2003):368-371.
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