兰州大学机构库 >第二临床医学院
Sparse whole-genome sequencing identifies two loci for major depressive disorder
ESI NOTE2017-07-19;Highly Cited Papers
2015-07-30
Source PublicationNATURE
ISSN0028-0836
Volume523Issue:7562Pages:588
AbstractMajor depressive disorder (MDD), one of the most frequently encountered forms ofmental illness and a leading cause of disability worldwide(1), poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified(2), despite analysis of more than 9,000 cases(3). Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 x 10(-10)), the other in an intron of the LHPP gene (P = 6.45 x10(-12)). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness.
Subject AreaScience & Technology - Other Topics
PublisherNATURE PUBLISHING GROUP
DOI10.1038/nature14659
Publication PlaceLONDON
Indexed BySCIE ; ESI
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) ; 美国国立卫生研究院项目 ; 英国惠康基金会项目
Project NumberWellcome Trust [WT090532/Z/09/Z, WT083573/Z/07/Z, WT089269/Z/09/Z, WT097307] ; NIH [MH-100549] ; Brain and Behavior Research Foundation ; Agency of Science, Technology and Research (A*STAR) Graduate Academy ; ERC [617306] ; 973 Program [2013CB531301] ; NSFC [31430048, 31222031]
WOS IDWOS:000358655200044
Funding OrganizationNSFC ; MOST ; NIH ; Wellcome Trust
SubtypeArticle
IRIDWOS:000358655200044
Department
[Cai, Na;
Kretzschmar, Warren;
Li, Yihan;
Fu, Guangyi;
Marchini, Jonathan;
Mott, Richard;
Flint, Jonathan] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England;
[Bigdeli, Tim B.;
Reimers, Mark;
Webb, Todd...更多
Citation statistics
Cited Times:503[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/179379
Collection第二临床医学院
Corresponding AuthorCai, N (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.
Recommended Citation
GB/T 7714
Cai, N,Bigdeli, TB,Kretzschmar, W,et al. Sparse whole-genome sequencing identifies two loci for major depressive disorder[J]. NATURE,2015,523(7562):588.
APA Cai, N.,Bigdeli, TB.,Kretzschmar, W.,Li, YH.,Liang, JQ.,...&Cai, N .(2015).Sparse whole-genome sequencing identifies two loci for major depressive disorder.NATURE,523(7562),588.
MLA Cai, N,et al."Sparse whole-genome sequencing identifies two loci for major depressive disorder".NATURE 523.7562(2015):588.
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