Sparse whole-genome sequencing identifies two loci for major depressive disorder

doi:10.1038/nature14659

兰州大学机构库 >第二临床医学院

	Sparse whole-genome sequencing identifies two loci for major depressive disorder
	Cai, N; Bigdeli, TB; Kretzschmar, W; Li, YH; Liang, JQ; Song, L; Hu, JC; Li, QB; Jin, W; Hu, ZF; Wang, GB; Wang, LM; Qian, PY; Liu, Y; Jiang, T; Lu, Y...更多 Cai, N; Bigdeli, TB; Kretzschmar, W; Li, YH; Liang, JQ; Song, L; Hu, JC; Li, QB; Jin, W; Hu, ZF; Wang, GB; Wang, LM; Qian, PY; Liu, Y; Jiang, T; Lu, Y; Zhang, XQ; Yin, Y; Li, YR; Xu, X; Gao, JF; Reimers, M; Webb, T; Riley, B; Bacanu, S; Peterson, RE; Chen, YP; Zhong, H; Liu, ZR; Wang, G; Sun, J; Sang, H; Jiang, GQ; Zhou, XY; Li, Y; Li, Y; Zhang, W; Wang, XY; Fang, X; Pan, RD; Miao, GD; Zhang, QW; Hu, J; Yu, FY; Du, B; Sang, WH; Li, KQ; Chen, GB; Cai, M; Yang, LJ; Yang, DL; Ha, BW; Hong, XH; Deng, H; Li, GY; Li, K; Song, Y; Gao, SG; Zhang, JB; Gan, ZY; Meng, HQ; Pan, JY; Gao, CG; Zhang, KR; Sun, N; Li, YH; Niu, QH; Zhang, YT; Liu, TQ; Hu, CM; Zhang, Z; Lv, LX; Dong, JC; Wang, XP; Tao, M; Wang, XM; Xia, J; Rong, H; He, Q; Liu, TB; Huang, GP; Mei, QY; Shen, ZM; Liu, Y; Shen, JH; Tian, T; Liu, XJ; Wu, WY; Gu, DH; Fu, GY; Shi, JG; Chen, YC; Gan, XC; Liu, LF; Wang, LN; Yang, FZ; Cong, EZ; Marchini, J; Yang, HM; Wang, J; Shi, SX; Mott, R; Xu, Q; Wang, J; Kendler, KS; Flint, J; Cai, N (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.收起
ESI NOTE	2017-07-19;Highly Cited Papers
	2015-07-30
Source Publication	NATURE
ISSN	0028-0836
Volume	523 Issue:7562 Pages:588
Abstract	Major depressive disorder (MDD), one of the most frequently encountered forms ofmental illness and a leading cause of disability worldwide(1), poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified(2), despite analysis of more than 9,000 cases(3). Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 x 10(-10)), the other in an intron of the LHPP gene (P = 6.45 x10(-12)). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness.
Subject Area	Science & Technology - Other Topics
Publisher	NATURE PUBLISHING GROUP
DOI	10.1038/nature14659
Publication Place	LONDON
Indexed By	SCIE ; ESI
Language	英语
First Inst	否
Funding Project	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划） ; 美国国立卫生研究院项目 ; 英国惠康基金会项目
Project Number	Wellcome Trust [WT090532/Z/09/Z, WT083573/Z/07/Z, WT089269/Z/09/Z, WT097307] ; NIH [MH-100549] ; Brain and Behavior Research Foundation ; Agency of Science, Technology and Research (A*STAR) Graduate Academy ; ERC [617306] ; 973 Program [2013CB531301] ; NSFC [31430048, 31222031]
WOS ID	WOS:000358655200044
Funding Organization	NSFC ; MOST ; NIH ; Wellcome Trust
Subtype	Article
IRID	WOS:000358655200044
Department	[Cai, Na; Kretzschmar, Warren; Li, Yihan; Fu, Guangyi; Marchini, Jonathan; Mott, Richard; Flint, Jonathan] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; [Bigdeli, Tim B.; Reimers, Mark; Webb, Todd...更多 [Cai, Na; Kretzschmar, Warren; Li, Yihan; Fu, Guangyi; Marchini, Jonathan; Mott, Richard; Flint, Jonathan] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; [Bigdeli, Tim B.; Reimers, Mark; Webb, Todd; Riley, Brien; Bacanu, Silviu; Peterson, Roseann E.; Kendler, Kenneth S.] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA; [Liang, Jieqin; Song, Li; Hu, Jingchu; Li, Qibin; Jin, Wei; Hu, Zhenfei; Wang, Guangbiao; Wang, Linmao; Qian, Puyi; Liu, Yuan; Jiang, Tao; Lu, Yao; Zhang, Xiuqing; Yin, Ye; Li, Yingrui; Xu, Xun; Yang, Huanming; Wang, Jian; Wang, Jun] BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China; [Gao, Jingfang] Zhejiang Tradit Chinese Med Hosp, Hangzhou 310000, Zhejiang, Peoples R China; [Chen, Yiping] Univ Oxford, CTSU, Oxford OX3 7LF, England; [Zhong, Hui] Anhui Mental Hlth Ctr, Hefei 230000, Anhui, Peoples R China; [Liu, Zhengrong] Anshan Psychiat Rehabil Hosp, Anshan 114000, Liaoning, Peoples R China; [Wang, Gang] Capital Univ Med Sci, Beijing Anding Hosp, Beijing 100000, Peoples R China; [Sun, Jing] Nanjing Med Univ, Brain Hosp, Nanjing 210000, Jiangsu, Peoples R China; [Sang, Hong] Changchun Mental Hosp, Changchun 130000, Jilin, Peoples R China; [Jiang, Guoqing; Zhou, Xiaoyan] Chongqing Mental Hlth Ctr, Chongqing 404100, Peoples R China; [Li, Yi] Dalian 7 Hosp, Dalian 116000, Liaoning, Peoples R China; [Li, Yi] Wuhan Mental Hlth Ctr, Wuhan 430000, Hubei, Peoples R China; [Zhang, Wei] Daqing 3 Hosp Heilongjiang, Daqing 163000, Heilongjiang, Peoples R China; [Wang, Xueyi] Hebei Med Univ, Hosp 1, Shijiazhuang 50000, Hebei, Peoples R China; [Fang, Xiang] Fuzhou Psychiat Hosp, Fuzhou 350000, Fujian, Peoples R China; [Pan, Runde] Guangxi Longquanshan Hosp, Guangxi 545000, Zhuangzu, Peoples R China; [Miao, Guodong] Guangzhou Psychiat Hosp, Guangzhou Brain Hosp, Guangzhou 510000, Guangdong, Peoples R China; [Zhang, Qiwen] Hainan Anning Hosp, Haikou 570100, Hainan, Peoples R China; [Hu, Jian] Harbin Med Univ, Haerbin 150000, Heilongjiang, Peoples R China; [Yu, Fengyu] Harbin 1 Special Hosp, Haerbin 150000, Heilongjiang, Peoples R China; [Du, Bo; Sang, Wenhua; Li, Keqing] Hebei Mental Hlth Ctr, Baoding 71000, Hebei, Peoples R China; [Chen, Guibing] Huaian 3 Hosp, Huaian 223001, Jiangsu, Peoples R China; [Cai, Min] Huzhou 3 Hosp, Huzhou 313000, Zhejiang, Peoples R China; [Yang, Lijun] Jilin Brain Hosp, Siping 136000, Jilin, Peoples R China; [Yang, Donglin] Jining Psychiat Hosp, Jining 272000, Shandong, Peoples R China; [Ha, Baowei] Liaocheng 4 Hosp, Liaocheng 252000, Shandong, Peoples R China; [Hong, Xiaohong] Shantou Univ, Mental Hlth Ctr, Shantou 515000, Guangdong, Peoples R China; [Deng, Hong] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610000, Sichuan, Peoples R China; [Li, Gongying] Jining Med Coll, Mental Hlth Inst, Jining 272000, Shandong, Peoples R China; [Li, Kan] Mental Hosp Jiangxi Prov, Nanchang 330000, Jiangxi, Peoples R China; [Song, Yan] Mudanjiang Psychiat Hosp Heilongjiang Prov, Mudanjiang 157000, Heilongjiang, Peoples R China; [Gao, Shugui] Ningbo Kang Ning Hosp, Ningbo 315000, Zhejiang, Peoples R China; [Zhang, Jinbei; Gan, Zhaoyu] Sun Yat Sen Univ, Hosp 3, Guangzhou 510630, Guangdong, Peoples R China; [Meng, Huaqing] ChongqingMed Univ, Hosp 1, Chongqing 400016, Peoples R China; [Pan, Jiyang] Jinan Univ, Hosp 1, Guangzhou 510000, Guangdong, Peoples R China; [Gao, Chengge] Xi An Jiao Tong Univ, Coll Med, Hosp 1, Xian, Shaan Xi, Peoples R China; [Zhang, Kerang; Sun, Ning] Shanxi Med Univ, Hosp 1, Taiyuan 30000, Shanxi, Peoples R China; [Li, Youhui; Niu, Qihui] Zhengzhou Univ, Hosp 1, Zhengzhou 450000, Henan, Peoples R China; [Zhang, Yutang] Lanzhou Univ, Hosp 2, Lanzhou 730000, Gansu, Peoples R China; [Liu, Tieqiao] Zhongnan Univ, Xiangya Hosp 2, Changsha 410000, Hunan, Peoples R China; [Hu, Chunmei] 3 Hosp Heilongjiang Prov, Beian 164000, Heilongjiang, Peoples R China; [Zhang, Zhen] Jiangsu Univ, Hosp 4, Zhenjiang 212000, Jiangsu, Peoples R China; [Lv, Luxian] Psychiat Hosp Henan Prov, Xinxiang 453000, Henan, Peoples R China; [Dong, Jicheng] Qingdao Mental Hlth Ctr, Qingdao 266000, Shandong, Peoples R China; [Wang, Xiaoping] Wuhan Univ, Renmin Hosp, Wuhan 430000, Hubei, Peoples R China; [Tao, Ming] Zhejiang Chinese Med Univ, Affiliated Hosp 2, Hangzhou 310000, Zhejiang, Peoples R China; [Wang, Xumei; Xia, Jing] China Med Univ, ShengJing Hosp, Shenyang 110001, Liaoning, Peoples R China; [Rong, Han] Kangning Hosp, Shenzhen Key Lab Psychol Healthcare, Shenzhen 518000, Guangdong, Peoples R China; [He, Qiang] Kanazawa Med Univ, Dept Gen Internal Med, Kahoku, Ishikawa 9200293, Japan; [Liu, Tiebang] Shenzhen Key Lab Psychol Healthcare, Shenzhen 518000, Guangdong, Peoples R China; [Liu, Tiebang] Shenzhen Kangning Hosp, Shenzhen 518000, Guangdong, Peoples R China; [Huang, Guoping] Sichuan Mental Hlth Ctr, Mianyang 621000, Sichuan, Peoples R China; [Mei, Qiyi] Suzhou Guangji Hosp, Suzhou 215000, Jiangsu, Peoples R China; [Shen, Zhenming] Tangshan 5 Hosp, Tangshan 63000, Hebei, Peoples R China; [Liu, Ying] ChinaMed Univ, Hosp 1, Shenyang 110001, Liaoning, Peoples R China; [Shen, Jianhua; Tian, Tian] Tianjin Anding Hosp, Tianjin 300000, Peoples R China; [Liu, Xiaojuan] Tianjin First Ctr Hosp, Tianjin 300000, Peoples R China; [Wu, Wenyuan] Tongji Univ Hosp, Shanghai 200000, Peoples R China; [Gu, Danhua] Weihai Mental Hlth Ctr, Weihai 264200, Shandong, Peoples R China; [Gu, Danhua] Weihai Mental Hlth Ctr, Weihai 264200, Shandong, Peoples R China; [Shi, Jianguo] Xian Mental Hlth Ctr, Xian 710000, Shaanxi, Peoples R China; [Chen, Yunchun] 4 Mil Med Univ, Xijing Hosp, Xian 710000, Shaanxi, Peoples R China; [Gan, Xiangchao] Max Planck Inst Plant Breeding Res, Dept Comparat Dev Genet, D-50829 Cologne, Germany; [Liu, Lanfen; Wang, Lina] Shandong Mental Hlth Ctr, Jinan 250000, Shandong, Peoples R China; [Yang, Fuzhong; Cong, Enzhao; Shi, Shenxun] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China; [Marchini, Jonathan] Univ Oxford, Dept Stat, Oxford OX1 3TG, England; [Shi, Shenxun] Fudan Univ, Huashan Hosp, Shanghai 200040, Peoples R China; [Xu, Qi] Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Beijing 10005, Peoples R China; [Xu, Qi] Chinese Acad Med Sci, Neurosci Ctr, Beijing 10005, Peoples R China; [Xu, Qi] Peking Union Med Coll, Beijing 10005, Peoples R China; [Wang, Jun] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark; [Wang, Jun] Macau Univ Sci & Technol, Taipa 999078, Macau, Peoples R China; [Wang, Jun] King Abdulaziz Univ, Princess Jawhara Ctr Excellence Res Hereditary Di, Jeddah 21589, Saudi Arabia; [Flint, Jonathan] East China NormalUnivers, Shanghai 200062, Peoples R China收起
Citation statistics	Cited Times:503[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	https://ir.lzu.edu.cn/handle/262010/179379
Collection	第二临床医学院
Corresponding Author	Cai, N (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.
Recommended Citation GB/T 7714	Cai, N,Bigdeli, TB,Kretzschmar, W,et al. Sparse whole-genome sequencing identifies two loci for major depressive disorder[J]. NATURE,2015,523(7562):588.
APA	Cai, N.,Bigdeli, TB.,Kretzschmar, W.,Li, YH.,Liang, JQ.,...&Cai, N .(2015).Sparse whole-genome sequencing identifies two loci for major depressive disorder.NATURE,523(7562),588.
MLA	Cai, N,et al."Sparse whole-genome sequencing identifies two loci for major depressive disorder".NATURE 523.7562(2015):588.

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