兰州大学机构库 >生命科学学院
Antifungal effect and action mechanism of antimicrobial peptide polybia-CP
Wang, KR; Jia, FJ; Dang, W; Zhao, YY; Zhu, RR; Sun, MY; Qiu, S; An, XP; Ma, ZL; Zhu, YY; Yan, JX; Kong, ZQ; Yan, WJ; Wang, R(王锐); Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
2016-01
Source PublicationJOURNAL OF PEPTIDE SCIENCE   Impact Factor & Quartile
ISSN1075-2617
Volume22Issue:1Pages:28-35
AbstractThe incidence of life-threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia-CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia-CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia-CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane-active action mode. In addition, polybia-CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia-CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright (c) 2015 European Peptide Society and John Wiley & Sons, Ltd.
Keywordantimicrobial peptide polybia-CP candidiasis antifungal ROS production
Subject AreaBiochemistry & Molecular Biology ; Chemistry
PublisherWILEY
DOI10.1002/psc.2835
Publication PlaceHOBOKEN
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 国家科技重大专项 ; 高等学校博士学科点专项科研基金 ; 中央高校基本科研业务费专项资金
Project NumberNational Natural Science Foundation of China [81573265, 20932003, 91213302, 21272102, 31200584, 21272108, 31401602] ; Key National S&T Program "Major New Drug Development' of the Ministry of Science and Technology [2012ZX09504001-003] ; Research Fund for the Doctoral Program of Higher Education of China [20120211120045] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-155, lzujbky-2015-279]
WOS IDWOS:000368731600002
Funding OrganizationNSFC ; MOST ; MOE ; LZU
SubtypeArticle
PMID 26680221
BIOSIS IDBCI:BCI201600204665
IRIDWOS:000368731600002
Department
[Wang, Kairong;
Jia, Fengjing;
Dang, Wen;
Zhao, Yanyan;
Zhu, Ranran;
Sun, Mengyang;
Qiu, Shuai;
An, Xiaoping;
Ma, Zelin;
Zhu, Yuanyuan...更多
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/181947
Collection生命科学学院
基础医学院
Corresponding AuthorYan, WJ; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Wang, KR,Jia, FJ,Dang, W,et al. Antifungal effect and action mechanism of antimicrobial peptide polybia-CP[J]. JOURNAL OF PEPTIDE SCIENCE,2016,22(1):28-35.
APA Wang, KR.,Jia, FJ.,Dang, W.,Zhao, YY.,Zhu, RR.,...&Wang, R .(2016).Antifungal effect and action mechanism of antimicrobial peptide polybia-CP.JOURNAL OF PEPTIDE SCIENCE,22(1),28-35.
MLA Wang, KR,et al."Antifungal effect and action mechanism of antimicrobial peptide polybia-CP".JOURNAL OF PEPTIDE SCIENCE 22.1(2016):28-35.
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