兰州大学机构库
pH-Sensitive nanoparticles as smart carriers for selective intracellular drug delivery to tumor
Li, Xin-Xin1,2; Chen, Jing1,2; Shen, JM(沈剑敏)1,2; Zhuang, Ran1; Zhang, Shi-Qi1; Zhu, Zi-Yun1; Ma, Jing-Bo1,2
2018-07-10
Source PublicationINTERNATIONAL JOURNAL OF PHARMACEUTICS   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN0378-5173
Volume545Issue:1-2Pages:274-285
AbstractHerein, a smart pH-sensitive nanoparticle (DGL-PEG-Tat-KK-DMA-DOX) was prepared to achieve the selective intracellular drug delivery. In this nanoparticle, a PEG-grafted cell penetrating peptide (PEG-Tat-KK) was designed and acted as the cell penetrating segment. By introducing the pH-sensitive amide bonds between the peptide and blocking agent (2,3-dimethylmaleic anhydride, DMA), the controllable moiety (PEG-Tat-KK-DMA) endowed the nanoparticle with a charge-switchable shell and temporarily blocked penetrating function, thus improving the specific internalization. Besides, dendrigraft poly-L-lysine (DGL) used as the skeleton can greatly improve the drug loading because of the highly dendritic framework. Under the stimuli of acidic pH, this nanoparticle exhibited a remarkable charge-switchable property. The drug release showed an expected behavior with little release in the neutral pH media but relatively fast release in the acidic media. The in vitro experiments revealed that the cellular uptake and cytotoxicity were significantly enhanced after the pH was decreased. In vivo biodistribution and antitumor research indicated that the nanoparticle had noteworthy specificity and antitumor efficacy with a tumor inhibition rate of 79.7%. These results verified this nanoparticle could efficiently improve the selective intracellular delivery and possessed a great potential in tumor treatment.
KeywordCell-penetrating peptide (CPP) Nanoparticles pH-Sensitive Intracellular delivery Tumor
DOI10.1016/j.ijpharm.2018.05.012
Indexed BySCIE ; PUBMED
Language英语
First Inst
Funding Project国家自然科学基金项目
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
Project NumberNational Natural Science Foundation of China Fund [81541060] ; Science and Technology Innovation Committee of Shenzhen Municipality [JCYJ20170818110340383]
WOS IDWOS:000433411000030
Funding OrganizationNSFC
PublisherELSEVIER SCIENCE BV
Original Document TypeArticle
PMID 29733971
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/196354
Collection兰州大学
生命科学学院
Corresponding AuthorShen, Jian-Min
Affiliation
1.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China
2.Shenzhen Following Precis Med Res Inst, Shenzhen, Peoples R China
First Author AffilicationSchool of Life Sciences
Corresponding Author AffilicationSchool of Life Sciences
Recommended Citation
GB/T 7714
Li, Xin-Xin,Chen, Jing,Shen, Jian-Min,et al. pH-Sensitive nanoparticles as smart carriers for selective intracellular drug delivery to tumor[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2018,545(1-2):274-285.
APA Li, Xin-Xin.,Chen, Jing.,Shen, Jian-Min.,Zhuang, Ran.,Zhang, Shi-Qi.,...&Ma, Jing-Bo.(2018).pH-Sensitive nanoparticles as smart carriers for selective intracellular drug delivery to tumor.INTERNATIONAL JOURNAL OF PHARMACEUTICS,545(1-2),274-285.
MLA Li, Xin-Xin,et al."pH-Sensitive nanoparticles as smart carriers for selective intracellular drug delivery to tumor".INTERNATIONAL JOURNAL OF PHARMACEUTICS 545.1-2(2018):274-285.
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