兰州大学机构库
Aconitic acid derived carbon dots: Conjugated interaction for the detection of folic acid and fluorescence targeted imaging of folate receptor overexpressed cancer cells
Qian, Jiali1; Quan, Feifei1; Zhao, Fengjiao1; Wu, Chengxin1; Wang, ZY(王兆彦)2; Zhou, L(周雷)1
2018-06
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL   Impact Factor & Quartile
ISSN0925-4005
Volume262Pages:444-451
AbstractHerein, we utilized aconitic acid (AA) as the precursor for preparing carbon dots (AA-CDs) by a facile hydrothermal reaction, and the resulting AA-CDs exhibited bright blue fluorescence with an absolute quantum yield of 56.5% in aqueous solution. Preliminary experiments showed that the prepared AA-CDs without further surface passivation or modification could selectively interact with folic acid (FA), resulting in significant fluorescence quenching. Based on this, a sensitive method for FA analysis was developed with a detection limit of 40 nM (S/N = 3), which was then successfully applied for the detection of FA in food and pharmaceutical samples with the average recoveries of 95.0-105.3%. Furthermore, a weak fluorescent nanoprobe (FA-AA-CDs) was fabricated based on the conjugated interaction of FA and AA-CDs, and its feasibility was evaluated as a fluorescence turn-on nanoprobe for targeted imaging of cancer cells using Hela, SMMC-7721, and A549 cells as models that expressed different levels of folate receptors (FRs) on the cell surface. The results exhibited that the fluorescence intensity of these cells was in accordance with their FRs expression levels, testifying its potential of FA-AA-CDs for targeted imaging of cancer cells. Subsequently, the internalization mechanism of FA-AA-CDs into cells was elucidated via receptor-mediated endocytosis using control experiments. (C) 2018 Elsevier B.V. All rights reserved.
KeywordAconitic acid Carbon dots Folic acid Folate receptor Cancer cell Cell imaging
DOI10.1016/j.snb.2018.01.227
Publication PlaceLAUSANNE
Indexed BySCIE
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
Project NumberNational Natural Science Foundation of China [21675069, 21527808, 21405067] ; Fundamental Research Funds for the Central Universities [lzujbky-2017-111]
WOS IDWOS:000427460600054
Funding OrganizationNSFC ; LZU
PublisherELSEVIER SCIENCE SA
Original Document TypeArticle
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/196768
Collection兰州大学
化学化工学院
药学院
Corresponding AuthorZhou, Lei
Affiliation
1.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China
First Author AffilicationCollege of Chemistry and Chemical Engineering
Corresponding Author AffilicationCollege of Chemistry and Chemical Engineering
First Signature AffilicationCollege of Chemistry and Chemical Engineering
Recommended Citation
GB/T 7714
Qian, Jiali,Quan, Feifei,Zhao, Fengjiao,et al. Aconitic acid derived carbon dots: Conjugated interaction for the detection of folic acid and fluorescence targeted imaging of folate receptor overexpressed cancer cells[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,262:444-451.
APA Qian, Jiali,Quan, Feifei,Zhao, Fengjiao,Wu, Chengxin,Wang, Zhaoyan,&Zhou, Lei.(2018).Aconitic acid derived carbon dots: Conjugated interaction for the detection of folic acid and fluorescence targeted imaging of folate receptor overexpressed cancer cells.SENSORS AND ACTUATORS B-CHEMICAL,262,444-451.
MLA Qian, Jiali,et al."Aconitic acid derived carbon dots: Conjugated interaction for the detection of folic acid and fluorescence targeted imaging of folate receptor overexpressed cancer cells".SENSORS AND ACTUATORS B-CHEMICAL 262(2018):444-451.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Qian, Jiali]'s Articles
[Quan, Feifei]'s Articles
[Zhao, Fengjiao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qian, Jiali]'s Articles
[Quan, Feifei]'s Articles
[Zhao, Fengjiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qian, Jiali]'s Articles
[Quan, Feifei]'s Articles
[Zhao, Fengjiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.