兰州大学机构库 >基础医学院
Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo
Shen, R(沈蓉)1; Liu, Disheng2; Hou, Chenchen1; Leu, Di1; Zhao, Lixia1,4; Cheng, J(程菊)1; Wang, DG(王德贵)3; Bai, DC(白德成)1
2017-10-01
Source PublicationFOOD & FUNCTION
ISSN2042-6496
Volume8Issue:17Pages:3636-3646
AbstractThe aim of this research was to investigate the antioxidant and anti-apoptotic activities of Potentilla anserina polysaccharide (PAP) on kidney damage induced by cadmium (Cd) in vitro and in vivo. PAP has been suggested to have anti-oxidation, anti-apoptosis, immunoregulation, antimicrobial, antitussive, and expectorant abilities. In this study, PAP was extracted and the major components of PAP were analyzed. It was shown that PAP pretreatment remarkably improved redox homeostasis, both in human embryonic kidney 293 (HEK293) cells and in BALB/c mice. Administration of PAP attenuated the mitochondrial dysfunction, degeneration, and fibrosis of kidney induced by Cd. Furthermore, PAP exhibited anti-apoptotic activity, which involved regulating both the mitochondria-mediated intrinsic apoptotic pathway and the death receptor-initiated extrinsic pathway. These results suggest that PAP is a potential therapeutic agent for Cd-induced nephrotoxicity.
Subject AreaBiochemistry & Molecular Biology ; Food Science & Technology
PublisherROYAL SOC CHEMISTRY
DOI10.1039/c7fo00495h
Publication PlaceCAMBRIDGE
Indexed ByEI ; SCIE ; PUBMED ; MEDLINE
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
Project NumberFundamental Research Funds for the Central Universities [lzujbky-2016-61] ; National Natural Science Foundation of China [81472541]
WOS IDWOS:000413199800020
Funding OrganizationNSFC ; LZU
EI Accession Number20174304296342
SubtypeArticle
EI KeywordsCadmium ; Cell death ; Mammals
EI Classification NumberBiological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals:549.3
PMID 28905953
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/197909
Collection基础医学院
Corresponding AuthorWang, Degui
Affiliation1.Institute of Integrated Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou; 730000, China
2.Department of Urologic Surgery, First Hospital, Lanzhou University, Lanzhou; 730000, China
3.Department of Anatomy and Histology, School of Basic Medical Sciences, Lanzhou University, Lanzhou; 730000, China
4.School of Nursing, Gansu University of Chinese Medicine, Lanzhou; 730000, China
First Author AffilicationSchool of Basic Medical Sciences
Corresponding Author AffilicationSchool of Basic Medical Sciences
Recommended Citation
GB/T 7714
Shen, Rong,Liu, Disheng,Hou, Chenchen,et al. Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo[J]. FOOD & FUNCTION,2017,8(17):3636-3646.
APA Shen, Rong.,Liu, Disheng.,Hou, Chenchen.,Leu, Di.,Zhao, Lixia.,...&Bai, Decheng.(2017).Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo.FOOD & FUNCTION,8(17),3636-3646.
MLA Shen, Rong,et al."Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo".FOOD & FUNCTION 8.17(2017):3636-3646.
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