| Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo | |
Shen, R(沈蓉)1 ; Liu, Disheng2; Hou, Chenchen1; Leu, Di1; Zhao, Lixia1,4; Cheng, J(程菊)1; Wang, DG(王德贵)3; Bai, DC(白德成)1 | |
| 2017-10-01 | |
| Source Publication | FOOD & FUNCTION
 |
| ISSN | 2042-6496 |
| Volume | 8Issue:17Pages:3636-3646 |
| Abstract | The aim of this research was to investigate the antioxidant and anti-apoptotic activities of Potentilla anserina polysaccharide (PAP) on kidney damage induced by cadmium (Cd) in vitro and in vivo. PAP has been suggested to have anti-oxidation, anti-apoptosis, immunoregulation, antimicrobial, antitussive, and expectorant abilities. In this study, PAP was extracted and the major components of PAP were analyzed. It was shown that PAP pretreatment remarkably improved redox homeostasis, both in human embryonic kidney 293 (HEK293) cells and in BALB/c mice. Administration of PAP attenuated the mitochondrial dysfunction, degeneration, and fibrosis of kidney induced by Cd. Furthermore, PAP exhibited anti-apoptotic activity, which involved regulating both the mitochondria-mediated intrinsic apoptotic pathway and the death receptor-initiated extrinsic pathway. These results suggest that PAP is a potential therapeutic agent for Cd-induced nephrotoxicity. |
| Subject Area | Biochemistry & Molecular Biology ; Food Science & Technology |
| Publisher | ROYAL SOC CHEMISTRY |
| DOI | 10.1039/c7fo00495h |
| Publication Place | CAMBRIDGE |
| Indexed By | EI ; SCIE ; PUBMED ; MEDLINE |
| Language | 英语 |
| First Inst | 是 |
| Funding Project | 国家自然科学基金项目 ; 中央高校基本科研业务费专项资金 |
| Project Number | Fundamental Research Funds for the Central Universities [lzujbky-2016-61] ; National Natural Science Foundation of China [81472541] |
| WOS ID | WOS:000413199800020 |
| Funding Organization | NSFC ; LZU |
| EI Accession Number | 20174304296342 |
| Subtype | Article |
| EI Keywords | Cadmium ; Cell death ; Mammals |
| EI Classification Number | Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals:549.3 |
| PMID | 28905953 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/197909 |
| Collection | 基础医学院 |
| Corresponding Author | Wang, Degui |
| Affiliation | 1.Institute of Integrated Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou; 730000, China 2.Department of Urologic Surgery, First Hospital, Lanzhou University, Lanzhou; 730000, China 3.Department of Anatomy and Histology, School of Basic Medical Sciences, Lanzhou University, Lanzhou; 730000, China 4.School of Nursing, Gansu University of Chinese Medicine, Lanzhou; 730000, China |
| First Author Affilication | School of Basic Medical Sciences |
| Corresponding Author Affilication | School of Basic Medical Sciences |
| Recommended Citation GB/T 7714 | Shen, Rong,Liu, Disheng,Hou, Chenchen,et al. Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo[J]. FOOD & FUNCTION,2017,8(17):3636-3646. |
| APA | Shen, Rong.,Liu, Disheng.,Hou, Chenchen.,Leu, Di.,Zhao, Lixia.,...&Bai, Decheng.(2017).Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo.FOOD & FUNCTION,8(17),3636-3646. |
| MLA | Shen, Rong,et al."Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo".FOOD & FUNCTION 8.17(2017):3636-3646. |
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