| Other Abstract | Objective: To detect serum changes of tumor marker CA125, HE4, CA199 in ovarian cancer patients in the process of adjuvant chemotherapy after the initial postoperative and explore its clinical monitoring value.Methods: Enrolling fifty-one patients at the First Hospital of Lanzhou University gynecology department,detecting serum level of CA125, HE4, CA199 and the three in all of the clinical patients by pathological diagnosis of ovarian cancer after each cycle of postoperative chemotherapy and during follow-up after treatment, analyzing significance of levels changes.Results: 1 The levels of CA125, HE4 ovarian cancer patients before chemotherapy after surgery were significant difference with lymph node metastasis, clinical stage, histological type, the degree of differentiation, while the CA199 only with significant difference in surgical pathology ; 2 33 cases of CR+PR group, there was a statistically significant difference with the level of CA125, HE4 and combined detection before and after chemotherapy; 18 patients of SD+PD group, there had significant difference with the level of CA125, HE4, CA199 and combined detection before and after chemotherapy;3 The susceptibility of early diagnosis of the recurrent ovarian cancer of CA125,HE4,CA199 respectively are 45.4%, 63.6%, 9.1% and the specificity respectively are87.1%, 93.5%, 80.6%, the sensitivity and specificity of the three joint detection separately are 66.6%, 96.3%.ROC curve shows that HE4 value of early predictionof the recurrence ovarian cancer is higher than CA125, CA199, combined detection is higher than any single detection. Conclusion: 1 CA125 and HE4 high level or positive may indicate that it is closely related to the biological behavior of the erosion and distant metastasis of ovarian cancer,but positive rate of CA199 levels can not fully reflect the biological behavior of ovarian cancer progress; 2Regular testing of CA125, HE4, CA199 and combined detection level with ovarian cancer patients have better clinical significance of determining its clinical efficacy and prediction of recurrence; 3 With prediction of recurrence ovarian cancer after surgery, the sensitivity and specificity of HE4 is superior to CA125 and CA199, the three combined detection can improve the sensitivity and specificity of early recurrence diagnosis of ovarian cancer after surgery . |
