代谢综合征与子宫内膜癌发病风险的Meta分析

兰州大学机构库 >第一临床医学院

	代谢综合征与子宫内膜癌发病风险的Meta分析
Alternative Title	Metabolic syndrome and risk of endometrial cancer:a meta-analysis
	马守叶
Subtype	硕士
Thesis Advisor	王海琳
	2016-05-23
Degree Grantor	兰州大学
Place of Conferral	兰州
Degree Name	硕士
Keyword	代谢综合征子宫内膜癌胰岛素抵抗 Meta分析
Abstract	目的：应用Meta分析系统评价代谢综合征与子宫内膜癌发病风险之间的关系，寻找影响子宫内膜癌发病风险增加的危险因素。方法：计算机检索PubMed、Web of Science和Cochrane图书馆、CBM、CNKI、万方数据库等数据库，应用关键词或主题词“代谢综合征”、“胰岛素抵抗综合征”、“X综合征”、“子宫内膜癌”、“子宫体癌” 、“Metabolic Syndrome”、“Insulin-Resistance Syndrome”、“Syndrome X ”、“Endometrial Neoplasm”、“Endometrial Cancer”、“Endometrial Carcinoma”、“Corpus Uteri Cancer”检索2014－10以前发表的关于子宫内膜癌与代谢综合征关系的中英文文献，应用Stata 12.0软件统计，最后用Egger’ｓ检验分析纳入文献发表有无偏倚。结果：最终检索到符合纳入及排出标准的文献共5篇,包括4个病例对照研究和1个队列研究，Meta分析结果显示，代谢综合征与子宫内膜癌的发病风险增加密切相关[相对危险度=1.96，95％可信区间(1.32,2.89)，P=0.001]。结论：代谢综合征为子宫内膜癌发病风险增加的危险因素，其中，肥胖/高腰围与子宫内膜癌的关系最为密切，可能为代谢综合征影响子宫内膜癌形成的关键因素；低水平高密度脂蛋白-胆固醇不是子宫内膜癌发生的高危因素。
Other Abstract	Objective：To assess the association between metabolic syndrome and risk of endometrial cancer using meta-analysis,in order to find risk factors increasing the risk of endometrial cancer,prevent the happening of the endometrial carcinoma. Methods：We searched references from CBM、CNKI、Wangfang 、PubMed、Web of Science and Cochrane Library before October 2014 to select cohort and case-control studies in both English and Chinese articles on the association between metabolic syndrome and risk of endometrial cancer.All of the articles were searched using “Metabolic Syndrome”,“Insulin-Resistance Syndrome”,“Syndrome X ”,“Endometrial Neoplasm”,“Endometrial Cancer”,“Endometrial Carcinoma”and“Corpus Uteri Cancer”.Two evaluators independently reviewed and selected articles based on predetermined selection criteria and assessed articles with Newcastle-Ottawa Quality Scale,NOS.Stata 12.0 was used to conduct meta-analysis.Q test and I2 were used to conduct heterogeneity test.Egger's test was used to analysis publication bias. Results：A total of 5 studies which met initial criteria were included in the final analyses,including four case-control study and one cohort studies,involved 428665 participants and 3112 cases of endometrial cancer.The meta analysis results show that metabolic syndrome was associated with an increased risk of endometrial cancer(RR =1.96,95％CI:1.32-2.89,P=0.001).The risk estimates for any single factor of the syndrome were 1.86 (P<0.001) for higher values of body mass index and/or waist, 1.81 (P = 0.044) for hyperglycemia, 1.81 (P = 0.024) for higher blood pressure values, and 1.17 (P<0.001) for high triglyceride levels;there was no significant association with low levels of HDL-cholesterol(P =0.259). Conclusions：Metabolic syndrome is associated with an increased risk of endometrial cancer;among the components of the syndrome,obesity/high waist is more strongly associated with endometrial cancer,and it may be the key factor that metabolic syndrome affects the formation of endometrial cancer.Low levels of HDL-cholesterol is not the high risk factor of endometrial carcinoma.
URL	查看原文
Language	中文
Document Type	学位论文
Identifier	https://ir.lzu.edu.cn/handle/262010/201284
Collection	第一临床医学院
Recommended Citation GB/T 7714	马守叶. 代谢综合征与子宫内膜癌发病风险的Meta分析[D]. 兰州. 兰州大学,2016.

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