| 室性期前收缩患者心室复极储备功能评价 |
| Alternative Title | The repolarization reserve function 0f patients with ventricular premature beat
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| 路宁 |
| Subtype | 硕士
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| Thesis Advisor | 姚亚丽
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| 2016-05-18
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 复极储备
室性期前收缩
QTc间期
QTd
Tp-ec间期
Tp-ed
Tp-e/QT比值
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| Abstract | 目的：探讨QTc间期、QTd、Tp-ec间期、Tp-ed、Tp-e/QT比值对室性期前收缩患者复极储备功能的评价作用。
方法：入选窦性心律合并室性期前收缩患者229例，根据室性期前收缩后窦性心动周期中QT间期的恢复，将QT间期恢复异常者纳入观察组，将恢复正常者纳入对照组，比较组间QTc间期、QTd、Tp-ec间期、Tp-ed、室性心动过速（室速）发作的差异性；分别比较组内不同心率下QTc间期的变化；评价QTc间期、QTd、Tp-ec间期、Tp-ed、Tp-e/QT比值对室性期前收缩患者心室复极异常的诊断价值。
结果：
1、观察组与对照组组间性别、年龄、QTd无统计学差异。QTc间期、Tp-ec间期、Tp-ed有统计学差异。室速发作（17例、5例），发生率有统计学差异；
2、观察组、对照组不同心率下QTc间期变化均有统计学差异（均P＜0.05）；
3、QTc间期、Tp-ec间期、Tp-e/QT比值对复极储备异常有诊断价值，QTd、Tp-ed、对复极储备异常无诊断价值。各指标诊断复极储备异常的最佳界值如下：男性QTc间期≥458ms，女性QTc间期≥469ms，Tp-ec间期≥95ms，Tp-e/QT比值≥0.22。
结论：QTc间期、QTd、Tp-ec间期、Tp-ed、Tp-e/QT比值是适用于评价室性期前收缩患者心室复极储备功能异常的无创性指标，结合室性期前收缩后QT间期的动态性变化可提高诊断的准确度。对SCD高危人群的早期诊断及预防性治疗有指导作用。 |
| Other Abstract | Purpose: To investigate the value of corrected QT interval、QTd、Tp-ec interval、Tp-ed、Tp-e/QT ratio for The repolarization reserve founction in patients with ventricular premature beat.Methods:229 cases of sinus rhythm with ventricular premature beat were included，according to the recovery of QT interval in sinus cycle length behind ventricular premature beat，whose QT interval recovery was abnormal would be brought into the observation group, and the normal brought into the control group,To compare the differences of corrected QT interval、QTd、Tp-ec interval、Tp-ed、and incidence of ventricular tachycardia between two groups.Evaluating the diagnosis value of corrected QT interval、QTd、Tp-ec interval、Tp-ed、Tp-e/QTratio in patients with ventricular premature beat.
Results:1.Between observation group and control group, gender, age, QTd had no statistical differences,corrected QT interval,Tp-ec interval,Tp-ed,and incidence of ventricular tachycardia had statistical differences.2.Under different heart rate，the change of corrected QT interval had statistical differences.
3.Corrected QT interval,Tp-ec interval, Tp-e/QT ratio has diagnostic value to the repolarization reserve dysfunction, QTd has no diagnostic value .The best diagnosis boundary value of each index to repolarization reserve dysfunction is: male QTc ≥458 ms and female QTc ≥ 469 ms, Tp-ec ≥ 95 ms , TPe/QT ratio ≥ 0.22. Conclusions: QTc, QTd, Tp-ec, Tp-ed, Tp-e/QT ratio as noninvasive indexes is applicable to evaluate the repolarization reserve function 0f patients with ventricular premature beat.And they can improve the accuracy of diagnosis if combined with the dynamic changing of QT interval after with ventricular premature beat.it has diagnosis value and guiding effect for SCD. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/201296
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| Collection | 第一临床医学院
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Recommended Citation
GB/T 7714 |
路宁. 室性期前收缩患者心室复极储备功能评价[D]. 兰州. 兰州大学,2016.
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