| Other Abstract | Objective:To investigate the effect of laparoscopic operation on body stressand immune function in patients with gallbladder stone complicated with acute cholecystitis.
Methods:103 cases of patients with gallbladder stone complicated with acute cholecystitis in our hospital were divided into laparoscopic operation surgery and traditional surgery group.There were 56 cases in laparoscopic surgery group,and 47 cases in traditional open surgery group.Both laparos-copic and traditional surgerywere were respectively performed within 72h. Operation time, intraoperative blood loss, incision length, postoperative bed activity time and hospitalization timein operative process of two groups were observed.In addition, 1,3 and 7 days before and after operation, the body stressindexes, and blood sugar were observedin two groups,and at each tim-epoint the indexes of T lymphocyte subsets, NK cell number, immunoglobulin, complement and other immune functions of patients in two groups were ob-served.All patients were reviewed 3 months after surgery. The scar lengthand complications were observed and compared. The lifequality of patients were evaluated by lifequality of questionnaire.
Results:(1)There were no significant difference in serum IL-6, CRP, cor-tisol, ACTH, and blood glucose levels in two groups before operation,and on 1st day, 3rd,days and 7th days after operation, their levels in the laparoscopic operation group were significantly lower than those in traditional surgery gr-oup.And compared with those before operation, IL-6, CRP, cortisol, ACTH, and blood glucose levels on 1stday and 3rd days in laparoscopic operation group,and all the indexes in the traditional surgery group were significantly higher.All indexed in two group decreased when compared with those on 1st day after operation.Compared with those on 3rd days after operation,IL-6, c-ortisol and blood glucose in the laparoscopic surgery group and all the in-dexes in the traditional surgery group were significantly lower.
(2)There were no significant difference in CD3, CD4, CD8, CD4/CD8,NK cell numbers, IgA, IgM, IgG, C3, C4 in two groups before operation,and the differences of all the indexes in two groups after operation were statistically significant on 1st day after operation.And the difference of CD3, CD4, CD8, CD4/CD8,NK cell numbers, IgA, IgM, IgG, C3 on 3rd day after operation were statistically significant.And the difference of CD3, CD4, CD4/CD8, C47th day after operation were statistically si... |
