| 胆囊壁的厚度结合声辐射力脉冲成像、门静脉宽度及生化指标评估肝炎后肝纤维化 |
| Alternative Title | Gallbladder wall thickness combined with Acoustic radiation force impluse imaging, the portal vein width and biochemical to assess liver fibrosis caused by hepatitis
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| 兰琼 |
| Subtype | 硕士
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| Thesis Advisor | 马苏美
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| 2016-05-20
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 肝纤维化
胆囊壁
肝脏弹性指数
门静脉宽度
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| Abstract | 目的 本研究旨在探讨肝炎后肝纤维化胆囊壁的厚度与肝纤维化的进展及其严重程度的关系，并同时研究声辐射力脉冲成像（ARFI）所得的弹性指数、门静脉宽度及部分生化指标与胆囊壁的厚度及纤维化程度的关系，为临床诊治提供参考。方法 回顾性分析2014年3月至2015年3月兰州大学第一医院收住的确诊为不同阶段肝纤维化并行声辐射力脉冲成像检查的76例患者。所有纳入病例均有明确肝病病史、典型临床表现及生化实验室检查。排除既往有胆囊疾病及已行胆囊切除术的患者。收集患者相应的胆囊壁厚度、肝脏弹性指数、门静脉宽度及有无腹水、血清白蛋白、血胆红素、凝血酶原时间等相关检查数据。根据Child-Pugh肝功能分级将肝纤维化分为3级，用SPSS19.0统计软件进行数据分析及处理。结果 肝纤维化的分级与胆囊壁厚度、肝脏弹性指数、门脉宽度、血清白蛋白及腹水量呈正相关（P<0.05），差异均具有统计学意义；而胆囊壁厚度与弹性指数、腹水量亦呈正相关（P<0.05），与血清白蛋白呈负相关（P<0.05），差异亦具有统计学意义。结论 胆囊壁的厚度结合弹性指数、门脉宽度、血清白蛋白及腹水量可以评估纤维化的进展及其严重程度。同时胆囊壁的厚度也与弹性指数、门脉宽度、血清白蛋白和腹水量密切相关，故而胆囊壁厚度亦可作为独立指标评估肝纤维化。 |
| Other Abstract | Objective ：The objective of this study is to investigate the relationship between the thickness of gallbladder wall and the progress of hepatic fibrosis. Meanwhile, to discuss the relationship between the liver elasticity index, the width of potal vein, biochemical indices and the gallbladder wall thickness and the degree of fibrosis, in order to provide reference for clinical diagnosis and treatment.Methods ：To retrospectively analyze the 76 patients with diagnosis of the different stages of liver fibrosis from March 2014 to March 2015, who were admitted to our hospital and completed the parallel acoustic radiation force impulse imaging. All the patients had a history of liver disease, typical manifestation and laboratory tests. The patients with a history of gallbladder disease and had undergone cholecystectomy were excluded. The thickness of gallbladder wall, liver elasticity index, width of portal vein, the presence of ascites, serum albumin, serum bilirubin, and prothrombin time were noted. According to Child-Pugh Classification of liver function, the severity of liver fibrosis was divided into three grades. All the statistical calculations were made by using SPSS (Version 19.0). Results：The grade of hepatic fibrosis and gallbladder wall thickness, liver elasticity index, portal width, serum albumin and ascites volume were positively correlated (P <0.05), and there is a statistically significant difference. The gallbladder wall thickness and elasticity index and ascites volume were also positively associated (P <0.05), and negatively correlated with serum albumin (P <0.05), statistical significant difference was reached for these parameters.
Conclusion：The combined with thickness of the gallbladder wall, elasticity index, portal width, serum albumin and ascites can assess the progress and severity of fibrosis. And the gallbladder wall thickness is closely related with the elasticity index, portal width, serum albumin and ascites. Gallbladder wall thickness may be used as an independent indicator to estimate the liver fibrosis. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/201310
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| Collection | 第一临床医学院
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Recommended Citation
GB/T 7714 |
兰琼. 胆囊壁的厚度结合声辐射力脉冲成像、门静脉宽度及生化指标评估肝炎后肝纤维化[D]. 兰州. 兰州大学,2016.
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