第一临床医学院知识库

目的：综合评价X线修复交叉互补基因3 (X-ray repair cross-complementing group 3，XRCC3) Thr241Met单核苷酸基因多态性与胃癌易感性的关系。方法：计算机检索中国期刊全文数据库 (CNKI)、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库 (VIP)、万方数据库、PubMed、Cochrane Library，收集国内外公开发表的关于XRCC3 Thr241Met基因多态性与胃癌易感性的病例-对照研究相关文献。采用Stata12.0 软件进行统计学分析，计算合并比值比 (odd ratio，OR)及95％可信区间 (confidence interval，CI)。结果：共纳入12篇文献，从总的效应量分析，XRCC3 Thr241Met基因多态性与胃癌易感性无明显相关性，按种族进行亚组分析，提示在亚洲人群中隐性模型（MM vs MT+TT：OR=2.59，95%CI为1.98-3.39，P＜0.001）、等位模型（M vs T：OR=1.57，95%CI为1.05-2.35，P=0.028）、纯合子模型（MM vs TT：OR=3.39，95%CI为2.17-5.31，P＜0.001）均具有统计学意义。基于对照组来源及是否符合Hardy-Weinberg遗传平衡进行的亚组分析结果提示突变型与野生型无明显统计学意义。结论：在亚洲人群中，XRCC3 Thr241Met基因多态性中Met这一突变型可能与胃癌易感性有关。

Objective：To evaluate the relationship between Thr241Met polymorphism of X-ray repair cross-complementing group 3 (XRCC3) gene and gastric cancer susceptibility.Methods: The relevant published studies were retrieved from China national Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Science and Technology Periodicals Data, Wan Fang databases, PubMed and Cochrane Library with computer. The statistical analysis was conducted by the Stata 12.0 software. odd ratio (OR) and 95％confidence interval (CI) for XRCC3 Thr241Met polymorphism and gastric cancer were calculated.Results: This meta-analysis included 12 case-control studies. Although our meta-analysis indicated null association of XRCC3 gene rs861539 polymorphism between gastric cancer patients and controls under gross effect, the source of controls and whether conform to Hardy-Weinberg equilibrium. Stratified analysis by ethnicity demonstrated a significant association in Asians under recessive model（MM vs MT+TT：OR=2.59, 95%CI为1.98-3.39, P<0.001）, allelic model（M vs T：OR=1.57, 95%CI为1.05-2.35, P=0.028） and homozygous model（MM vs TT：OR=3.39, 95%CI为2.17-5.31, P<0.001).Conclusions：The XRCC3 Thr241Met polymorphism was associated with the risk for gastric cancer in Asian populations.