兰州大学机构库 >学院待认领
阻塞性睡眠呼吸暂停低通气综合征在2型糖尿病患者中的患病率及其对糖尿病脂代谢的影响
Alternative TitleThe Prevalence of Obstructive Sleep Apnea Hypopnea Syndrome in Type 2 Diabetes Mellitus and It’s Effects on Lipid Metabolism in Diabetes
安思芹
Thesis Advisor刘静
2014-05-23
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword阻塞性睡眠呼吸暂停低通气综合征 2型糖尿病 血脂异常 慢性间歇性缺氧
Abstract目的:了解阻塞性睡眠呼吸暂停低通气综合征(OSAHS)在2型糖尿病(T2DM)患者中的患病率,并探讨OSAHS对T2DM患者脂代谢的影响及其机制。 方法:住院2型糖尿病患者横断面观察性研究。所有纳入的2型糖尿病患者均被要求在住院部病房佩带ApneaLink便携式睡眠呼吸监测仪进行一整夜睡眠呼吸监测,血脂水平按常规酶法用奥林巴斯AU-5400全自动生化仪进行检测。 结果:1.150名2型糖尿病患者纳入研究,其中男性84名,女性66名,平均年龄为(59.9±11.1)岁。OSAHS整体患病率为68%,其中轻度、中度及重度OSAHS患者分别占37.3%、16.0%和14.7%;2.所有纳入的研究对象中大约有92%至少有一项血脂指标异常,其中最常见的形式为高低密度脂蛋白胆固醇血症,约占76.7%;3.高胆固醇血症(42.2% vs 20.8%, p<0.05)与低高密度脂蛋白胆固醇血症(52.9% vs 33.3%, p<0.05)的发生率,T2DM合并OSAHS组均高于单纯T2DM组,但是在调整混杂因素后OSAHS仅与低高密度脂蛋白胆固醇相关(OR, 2.359; 95%CI, 1.261–4.414; P = 0.007);4.血浆高密度脂蛋白胆固醇与氧减饱和度指数(ODI)值呈线性负相关。 结论:T2DM患者中OSAHS和血脂异常的患病率均很高。T2DM患者中OSAHS与低高密度脂蛋白胆固醇血症独立相关,呼吸暂停低通气指数(AHI)与ODI均为T2DM合并OSAHS患者发生低高密度脂蛋白胆固醇血症的独立预测因子,且ODI与血浆高密度脂蛋白胆固醇水平呈线性负相关,慢性间歇性缺氧可能是T2DM合并OSAHS患者发生脂代谢紊乱的潜在机制。
Other AbstractObjectives: The primary aim of the current study was to assess the prevalence of OSAHS in a group of adults with T2DM. A secondary objective was to explore the relationship between OSAHS and dyslipidemia in patients with type 2 diabetes. Methods: A cross-sectional study of adults with T2DM recruited randomly from Gansu Provincial hospital inpatient department of diabetes. All study participants had a diagnosis of T2DM and were asked to wear an ApneaLink(ResMed Corp, San Diego, CA) screening device for OSAHS (AHI≥5events/h) overnight in the hospital. Serum lipid levels were measured using the Olympus AU-5400 autoanalyzer by routine enzymatic methods. Results: One hundred and fifty patients were analyzed. There were 84 males and 66 females with a mean age of (59.91±11.14) years (range:29-80 years). The overall OSAHS prevalence was 68%(median apnea-hypopnea indes, 8; range,0-76), Regarding the severity of OSAHS, 37.3%, 16.0% and 14.7% had mild, moderate and severe OSAHS, respectively. Around 92% of all subjects had at least one lipid abnormality. Most common (76.7%) form of dyslipidemia found in all participants was raised LDL-C. Hypercholesterolemia(42.2% vs 20.8%, p<0.05) and Lower-HDL(52.9% vs 33.3%, p<0.05) prevalence was higher in patients with OSAHS than those without. After adjustment for possible confounders, OSAHS remained independently associated with lower-HDL(odds ratio, 2.359; 95% confidence interval, 1.261–4.414; P = 0.007). Conclusions: This study showed that both OSAHS and dyslipidemia have a high prevalence in adults with T2DM. Our study confirmed the independent association between OSAHS and lower-HDL in diabetic subjects. After adjustment for confounding factors, both AHI and ODI were independent predictors of lower-HDL. We identified chronic intermittent hypoxia as potential mechanism.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222128
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
安思芹. 阻塞性睡眠呼吸暂停低通气综合征在2型糖尿病患者中的患病率及其对糖尿病脂代谢的影响[D]. 兰州. 兰州大学,2014.
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