兰州大学机构库 >学院待认领
脂联素/瘦素比值用于非酒精性脂肪肝严重程度的可行性研究
Alternative TitleA feasibility study on adiponectin to leptin ratio for severity of nonalcoholic fatty liver disease
孔银
Thesis Advisor张岭漪
2011-05-23
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword脂联素/瘦素比值 非酒精性脂肪性肝病 胰岛素抵抗
Abstract目的:研究非酒精性脂肪性肝病(NAFLD)患者血清脂联素/瘦素(APN/LP, A/L)比值与胰岛素抵抗(IR)的关系, 探讨血清A/L对NAFLD严重程度分级中的意义。方法:78例确诊NAFLD患者,依据彩色超声诊断仪显像结果,分为轻度NAFLD组31例,平均年龄为50±14岁,男女性别比为19:12;中重度NAFLD组47例,平均年龄为49±14岁,男女性别比为27:20;同期观察体检健康志愿者30例作为对照组,平均年龄为48±12岁,性别比为18:12;各组平均年龄及性别无差异。(1)测量并计算各组BMI值;(2)ELISA法同期检测血清APN、LP水平及丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、甘油三酯(TG)、总胆固醇(CHO)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、空腹血糖/胰岛素(FG/FIN);(3)依据公式计算稳态模型评估的胰岛素抵抗指数HOMA-IR;(4)所有结果同期均与对照组对比。计量资料用均数±标准差( ±S)表示;计量资料差异性比较用方差分析;多因素相关性用pearson分析。结果:(1)血清LP与HOMA-IR、LDL和BMI均呈正相关(r=0.296,p=0.000;r=0.327, p=0.000和r=0.282,p=0.001);(2)血清APN与HOMA-IR、LDL和BMI均呈负相关(r=-0.375,p=0.000;r=-0.368,p=0.000和r=-0.285,p=0.001);(3)血清A/L与HOMA-IR、LDL和BMI均呈显著负相关(r=-0.398,p=0.000;r=-0.374, p=0.000和 r=-0.307,p=0.000),且NAFLD轻度组的相关系数(r= -0.311)小于中重度组(r= -0.486);
Other AbstractAIM: The aim of present study was to evaluate the significance of the ratio of adiponectin to leptin (A/L) in serum used for the severity of nonalcoholic fatty liver disease (NAFLD) by studying the relationship between the serum ratio of A/L and the serum IR in patients with NAFLD. Methods: 78 patients with NAFLD were divided into two groups determined by the abdominal ultrasound. The mild group of NAFLD (n=31, mean age 50±14, male/female 19:12) and the moderate-severe group of NAFLD (n=47, mean age 49±14, male/female 27:20).Normal control group(n= 30, mean age 48±10, male/female 18:12) were the healthy volunteers. The serum levels of leptin and adiponectin were measured by ELISA. The body mass index (BMI), alumina- aminotransferase (ALT), aspartate-aminotransferase (AST), triglyceride (TG), total cholesterol (CHO), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), fasting blood glucose (FBG), fasting insulin (FIN), homeostasis model assessment insulin resistan ce (HOMA-IR) were detected at the same time. Results:(1)The level of serum leptin were positiv ely correlated with HOMA-IR (r=0.296, p=0.000), LDL (r=0.327, p=0.000) and BMI (r=0.282, p=0.001).(2)The level of serum adiponectin levels were negatively correlated with HOMA-IR (r=-0.375, p=0.000), LDL (r=-0.368, p=0.000) and BMI (r=-0.285, p=0.001).(3)The ratio of A/L were negatively correlated with HOMA-IR (r=0.398, p=0.000),LDL (r=-0.374, p=0.000) and BMI (r=-0.307, p=0.000). The coefficient correlation of A/L ratio were significant lower in the mild group NAFLD (r= -0.311) compared with the moderate-severe group NAFLD (r= -0.486).
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222233
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
孔银. 脂联素/瘦素比值用于非酒精性脂肪肝严重程度的可行性研究[D]. 兰州. 兰州大学,2011.
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