| 乙肝患者血浆miR-122的含量变化及与实验室相关指标的关联性研究 |
| Alternative Title | Plasma mircoRNA-122 levels in patients with hepatitis B virus infection and relation with laboratory parameters
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| 黄琳淋 |
| Thesis Advisor | 李光迪
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| 2013-05-13
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 乙型肝炎
实时荧光定量RT-PCR
microRNA-122
天门冬氨酸氨基转移酶
丙氨酸氨基转移酶
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| Abstract | 目的：乙型肝炎病毒是引起肝癌的重要致病因素，在我国乙肝患者数量多，流行范围广。临床上主要通过检测乙肝病毒DNA复制水平、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）和乙肝三系统来监测乙肝病毒在肝内的活动情况和肝脏损伤情况，但各自均有局限性。miR-122是肝脏特异miRNA，不但参与肝脏的分化、生长等正常生理活动，也与肝炎、肝纤维化以及肝癌等肝脏疾病关系密切。本实验主要探讨miR-122在乙肝患者不同病毒DNA载量间的含量差异，分析其与乙肝病毒行为的相关性，并研究miR-122与肝脏损伤标志物丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）的关系，明确其是否能成为肝脏损伤的新型标志物。 |
| Other Abstract | Objective：Hepatitis B virus (HBV) is the most important pathogenic factor for hepatocellular carcinoma. A number of patients infect HBV in a wide range of China.HBV DNA ,alanine aminotransferase enzyme (ALT),aspartate aminotransferase (AST) and hepatitis B three system are usually used for monitoring HBV replication and estimating liver injure,but those markers are all have limitation.miR-122 is a liver-specific microRNA,it is not only involved in various physiological processes in hepatic such as growth ,differentiation and so on,but also in pathology.Here,we explored miR-122 levels in different groups,and investigated whether miR-122 levels correlate with viral replication.Furthermore,we examined the relation among miR-122 , ALT,AST,and whether miR-122 may be a new marker for liver injure. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/222359
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
黄琳淋. 乙肝患者血浆miR-122的含量变化及与实验室相关指标的关联性研究[D]. 兰州. 兰州大学,2013.
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