兰州大学机构库 >学院待认领
延胡索乙素对大鼠慢性神经病理性疼痛镇痛作用及机制的研究
Alternative TitleANALGESIC EFFECTS AND MECHANISMS OF LEVO-TETRAHYDROPALMATINE IN RATS’ MODEL OF CHRONIC CONSTRICTION INJURY NEUROPATHIC PAIN
王殊秀
Thesis Advisor冷玉芳
2012-05-22
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword延胡索乙素 CCI 脂肪酸酰胺水解酶 URB597 URB602
Abstract目的:研究延胡索乙素及分别与URB597、URB602联合应用对CCI大鼠的影响。 方法:成年Wistar大鼠84只,分为:假手术组(S)、对照组(C)、L-THP组(L)、L-THPURB597合用组(L1)、UL-THPRB602合用组(L2),S组仅暴露坐骨神经,其余组均建立CCI模型。术毕即刻L、L1和L2组腹腔注射L-THP 40mg/kg/d,L1、L2组术后11d开始,切口局部注射URB597、URB602 0.3mg/kg/d,术后3d、7d、14d三个取材时间点S、C和L组检测FAAH表达;其余大鼠测试机械热痛阈。 结果:L、L1、L2组术后机械痛阈和热痛阈显著提高(P<0.05),L组 FAAH表达明显降低(P<0.05)。 结论:L-THP对CCI大鼠具有良好的镇痛作用,可能与抑制FAAH的表达有关;与URB597、URB602联合应用时作用更佳。
Other AbstractTo evaluate the effects of Levo-tetrahydropalmatine ( L-THP, a traditional chinese medicine) in neuropathic pain of the rats’ model of sciatic nerve chronic constriction injury. Moreover, to observe the effects of combined L-THP with URB597、URB602 (specific irreversible inhibitors for fatty acid amide hydrolase FAAH and,monoacylglycerol lipase MAGL) respectively in neuropathic pain CCI rats’ model . Expression of FAAH was degraded in rats’ hippocampus of group L compare with group S and C in the post-operation 3d、7d and 14d three time-point(P<0.05). In CCI rats’ model, L-THP produced a favourable analgestic effects and, FAAH may involves in this effect, enhanced effects were observed when combined L-THP with URB597、URB602 respectively, suggesting that L-THP may bacome a promising target for the treatments of neuropathic pain.This may provides a new approch for exploring mechanisms and treatments of neuropathic pain .
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Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222393
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
王殊秀. 延胡索乙素对大鼠慢性神经病理性疼痛镇痛作用及机制的研究[D]. 兰州. 兰州大学,2012.
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