延胡索乙素对大鼠慢性神经病理性疼痛镇痛作用及机制的研究

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	延胡索乙素对大鼠慢性神经病理性疼痛镇痛作用及机制的研究
Alternative Title	ANALGESIC EFFECTS AND MECHANISMS OF LEVO-TETRAHYDROPALMATINE IN RATS’ MODEL OF CHRONIC CONSTRICTION INJURY NEUROPATHIC PAIN
	王殊秀
Thesis Advisor	冷玉芳
	2012-05-22
Degree Grantor	兰州大学
Place of Conferral	兰州
Degree Name	硕士
Keyword	延胡索乙素 CCI 脂肪酸酰胺水解酶 URB597 URB602
Abstract	目的：研究延胡索乙素及分别与URB597、URB602联合应用对CCI大鼠的影响。方法：成年Wistar大鼠84只，分为：假手术组（S）、对照组(C)、L-THP组(L)、L-THPURB597合用组（L1）、UL-THPRB602合用组（L2），S组仅暴露坐骨神经，其余组均建立CCI模型。术毕即刻L、L1和L2组腹腔注射L-THP 40mg/kg/d，L1、L2组术后11d开始，切口局部注射URB597、URB602 0.3mg/kg/d，术后3d、7d、14d三个取材时间点S、C和L组检测FAAH表达；其余大鼠测试机械热痛阈。结果：L、L1、L2组术后机械痛阈和热痛阈显著提高（P＜0.05），L组 FAAH表达明显降低（P＜0.05）。结论：L-THP对CCI大鼠具有良好的镇痛作用，可能与抑制FAAH的表达有关；与URB597、URB602联合应用时作用更佳。
Other Abstract	To evaluate the effects of Levo-tetrahydropalmatine ( L-THP, a traditional chinese medicine) in neuropathic pain of the rats’ model of sciatic nerve chronic constriction injury. Moreover, to observe the effects of combined L-THP with URB597、URB602 (specific irreversible inhibitors for fatty acid amide hydrolase FAAH and，monoacylglycerol lipase MAGL) respectively in neuropathic pain CCI rats’ model . Expression of FAAH was degraded in rats’ hippocampus of group L compare with group S and C in the post-operation 3d、7d and 14d three time-point（P＜0.05）. In CCI rats’ model, L-THP produced a favourable analgestic effects and, FAAH may involves in this effect, enhanced effects were observed when combined L-THP with URB597、URB602 respectively, suggesting that L-THP may bacome a promising target for the treatments of neuropathic pain.This may provides a new approch for exploring mechanisms and treatments of neuropathic pain .
URL	查看原文
Language	中文
Document Type	学位论文
Identifier	https://ir.lzu.edu.cn/handle/262010/222393
Collection	学院待认领
Affiliation	临床医学院
Recommended Citation GB/T 7714	王殊秀. 延胡索乙素对大鼠慢性神经病理性疼痛镇痛作用及机制的研究[D]. 兰州. 兰州大学,2012.

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