兰州大学机构库 >学院待认领
血浆可溶性晚期糖基化终末产物受体和APACHE II 评分对脓毒症预后的评价
Alternative TitlePrognostic value of plasma soluble advanced glycation end product receptor and APACHE II score for patient with sepsis
陈德
Thesis Advisor周荣
2015-05-20
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword可溶性晚期糖基化终末产物受体 急性生理与慢性健康状况评分II 脓毒症 预后
Abstract目的:探讨血期糖基化终末浆可溶性晚产物受体(sRAGE)和急性生理与慢性健康状况评分II(APACHE II)在预测脓毒症预后中的意义。方法:选择2013年2月至2014年8月于我院ICU收治的脓毒症患者79例。检测患者入院后第1日和第3日血浆sRAGE水平,同时记录当日APACHE II评分,根据28日生存与否分为生存组和死亡组,分析两组sRAGE水平、APACHE II评分于第1日、3日变化差异及相关性,并分析两项指标对脓毒症患者预后的判断价值。结果: 第1日、3日,存活组sRAGE水平及APACHE II评分均低于死亡组组(P<0.05);当日sRAGE水平与APACHE II评分之间均存在正相关(r=0.74,P<0.05;r=0.61,P<0.05);第1日,sRAGE水平和APACHE II评分对脓毒症预后判断的ROC曲线下面积分别为0.93、0.86(P<0.05),第3日,两指标的曲线下面积分别为0.75、0.69 (P<0.05)。结论: 脓毒症患者血浆sRAGE水平与APACHE II评分显著相关,血浆sRAGE水平可作为脓毒症患者转归的早期预测指标。
Other AbstractObjective: Investigate the significance of plasma soluble advanced glycation end product receptor and acute physiology and chronic health evaluation II (APACHE II) in evaluating and predicting prognosis in sepsis. Methods: 79 sepsis patients were collected in our hospital ICU form February 2013 to August 2014.The dynamic changes of plasma sRAGE were tested on the 1st, and the 3rd day. At the same time APACHE II score were recorded. Patients were divided into survival and non-survival group basing on survival rate of the 28th day to analyze its difference and correlation with plasma sRAGE and APACHE II score. The positive predictive value of two biomarkers, at the end, was also assessed. Results: The plasma sRAGE level and APACHE II score of survival group were lower than those of non-survival group on the 1st, and the 3rd day (P<0.05); Meanwhile, the plasma sRAGE level and APACHE II score positively correlated (r=0.74,P<0.05;r=0.61,P<0.05);On the 1st day, the plasma sRAGE level and APACHE II score area under the ROC curve were 0.93 and 0.86 (P<0.05); On the 3rd day, the plasma sRAGE level and APACHE II score area under the ROC curve were 0.75 and 0.69 (P<0.05).Conclusion: The plasma sRAGE level is obviously correlated with the APACHE Ⅱ score in patients with sepsis.And the plasma sRAGE level may be used as critical parameter in predicting the prognosis of sepsis.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222428
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
陈德. 血浆可溶性晚期糖基化终末产物受体和APACHE II 评分对脓毒症预后的评价[D]. 兰州. 兰州大学,2015.
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