|Alternative Title||Clinical application of a physical antimicrobial material for the prevention of catheter associated urinary tract infections
|Place of Conferral||兰州
|Other Abstract||Objective: Jieyoushen (JUC) is an antimicrobial material. We performed an clinical study to observe the effect of JUC on the prevention of CAUTI and the formation of biofilm on the catheter surface without the use of antibiotics, to provide new ideas on the clinical prevention of CAUTI.
Methods: In the randomized controlled clinical trial, Acute urinary retention patients in Urology Surgical with indwelling catheter were recruited to a multi-center, double-blind randomized controlled trial. Make a comparison of the bacteriuria incidence between JUC treated group and NS treated group after catheterization in 5 and 7 days and observe adverse drug reactions of JUC. In biofilm test, Catheters were treated with JUC or NS respectively before insertion into the urethra and removed on the 1, 2, 5, 7, or 10 days to make samples to observe the growth of biofilm by Scanning electron microscope (SEM) .
Results: In the randomized controlled clinical trial, The incidence of bacteriuria in catheterization were 3.10% in JUC treated group and 11.63% in NS treated group in the fifth day, and 23.81% in JUC treated group and 43.65% in NS treated group in the seventh day. The number of bacteria in the JUC treated group was significantly lower than that of the NS treated group (P<0.01). In biofilm test, SEM demonstrated that in the NS treated group, bacterial attachment and aggregation was observed after 1 day. Initial biofilms were seen on the 2nd catheterization day, and matured biofilms were seen on the 5th, 7th and 10th day. In contrast, no bacteria were seen after the 1 or 2nd day in the JUC group. Some bacterial attachment and early biofilm formation was seen on the 5th, 7th and 10th day. We found that both the external and internal surface of catheter were more susceptible to biofilm formation than the intrabladder part of the catheter. JUC application formed a honey-comb like antimicrobial membrane on the surface of the catheter, slowed biofilm formation, and degraded existing biofilms.
Conclusion: The formation of biofilm on the urethral catheter surface can be prevented effectively and the incidence of CAUTI can be reduced effectively by the physical anti-microbial method without the use of prophylactic antibiotics.|
马佩芬. 新型物理抗菌材料预防导尿管伴随性尿路感染的临床效果研究[D]. 兰州. 兰州大学,2015.
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