|Alternative Title||Analysis of Distribution and Drug Sensitivity of Pathogens in Neonatal Bacterial Infection
|Place of Conferral||兰州
|Other Abstract||Objective To monitor the distribution and drug sensitivity status of pathogens in neonatal bacterial infection and instruct clinical drug application.
Methods From June 2011 to May 2012, 323 cases of infectious diseases in newborns were collected specimens,then the specimens were made germiculture，then the results of the distribution and drug sensitivity of pathogens were statistically analyzed.
Results A total of 184 pathogens strains were isolated. 94 strainsof the pathogens were Gram-negative bacilli,which were mainly Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae ; Gram-postive cocci contained 90 strains,which were mainly Staphylococcus aureus ,epidermis Staphylococcus and hemolytic Staphylococcus . The most common pathogens of neonatal sepsis were Staphylococcus aureus, then in series Staphylococcus haemolyticus and Klebsiella pneumoniae.
The imipenem, Amikacin, cefoperazone and sulbactam, piperacillin and tazobactam sensitive rates of Gram negative bacilli was 97.3%,100%,77.8%,88.8%,respectively.The ceftriaxone, cefotaxime sensitive rates of Gram negative bacilli was below 40.0%.The cefoperazone, cefuroxime sensitive rates of Gram negative bacilli was lower than 25.0%.The piperacillin sensitive rate of Gram negative bacilli was below 15.0%.The linezolid ,vancomycin sensitive rate of Gram-positive bacteria was 100%.The penicillin sensitive rate of Gram-positive bacteria was lower than 15.0%. While the teicoplanin sensitive rate of Staphylococcus epidermidis was 93.8%.
Conclusion The main pathogens of neonatal infectious disease is Gram-negative bacteria, which includes Escherichia coli and Klebsiella pneumoniae .Gram-positive pathogens consist of Staphylococcus aureus and Staphylococcus aureus. Different bacteria is isolated in different seasons and regions. The commonly used first-line and second-line antibiotics sensitive rates of bacteria are low, and selecting sensitive antibiotics is the key to effective treatment of neonatal infections.|
王君棪. 新生儿细菌感染性疾病的病原分布及药敏分析[D]. 兰州. 兰州大学,2013.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.