兰州大学机构库 >学院待认领
新生儿细菌感染性疾病的病原分布及药敏分析
Alternative TitleAnalysis of Distribution and Drug Sensitivity of Pathogens in Neonatal Bacterial Infection
王君棪
Thesis Advisor王爱华
2013-05-16
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword新生儿 病原菌 药敏试验 抗生素
Abstract目的 监测新生儿感染性疾病的病原分布及药敏状况,为合理使用抗菌药物提供依据。 方法 回顾性分析2011年6月至2012年5月323例感染性疾病新生儿各种标本的细菌培养及分离菌株药敏结果,进行统计学分析。 结果 共分离出184株病原菌,其中革兰氏阴性菌为94株,主要为大肠埃希氏菌37株、肺炎克雷伯杆菌27株及阴沟肠杆菌10株;革兰氏阳性菌为90株,包括金黄色葡萄球菌24株、表皮葡萄球菌18株及溶血葡萄球菌11株。新生儿败血症前三位病原菌依次为:表皮葡萄球菌、溶血性葡萄球菌、肺炎克雷伯杆菌。 革兰氏阴性菌对亚胺培南敏感性为97.3%、阿米卡星100%、头孢哌酮舒巴坦77.8%、哌拉西林他唑巴坦88.8%,对头孢曲松、头孢噻肟敏感性低于40.0%、头孢哌酮、头孢呋辛低于25.0%,哌拉西林低于15.0%;革兰氏阳性菌对利奈唑胺、万古霉素敏感性为100%,对青霉素敏感性均低于15.0%,对替考拉宁敏感性为93.8%。 结论 新生儿感染性疾病病原主要为革兰氏阴性菌,包括大肠埃希菌、肺炎克雷伯菌;革兰阳性病原以金黄色葡萄球菌及表皮葡萄球菌为主。不同季节及地区检出病原菌不同。细菌对常用的一线、二线抗生素敏感性较低。合理、及时的选择敏感的抗菌药物是有效治疗新生儿感染性疾病的关键。
Other AbstractObjective To monitor the distribution and drug sensitivity status of pathogens in neonatal bacterial infection and instruct clinical drug application. Methods From June 2011 to May 2012, 323 cases of infectious diseases in newborns were collected specimens,then the specimens were made germiculture,then the results of the distribution and drug sensitivity of pathogens were statistically analyzed. Results A total of 184 pathogens strains were isolated. 94 strainsof the pathogens were Gram-negative bacilli,which were mainly Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae ; Gram-postive cocci contained 90 strains,which were mainly Staphylococcus aureus ,epidermis Staphylococcus and hemolytic Staphylococcus . The most common pathogens of neonatal sepsis were Staphylococcus aureus, then in series Staphylococcus haemolyticus and Klebsiella pneumoniae. The imipenem, Amikacin, cefoperazone and sulbactam, piperacillin and tazobactam sensitive rates of Gram negative bacilli was 97.3%,100%,77.8%,88.8%,respectively.The ceftriaxone, cefotaxime sensitive rates of Gram negative bacilli was below 40.0%.The cefoperazone, cefuroxime sensitive rates of Gram negative bacilli was lower than 25.0%.The piperacillin sensitive rate of Gram negative bacilli was below 15.0%.The linezolid ,vancomycin sensitive rate of Gram-positive bacteria was 100%.The penicillin sensitive rate of Gram-positive bacteria was lower than 15.0%. While the teicoplanin sensitive rate of Staphylococcus epidermidis was 93.8%. Conclusion The main pathogens of neonatal infectious disease is Gram-negative bacteria, which includes Escherichia coli and Klebsiella pneumoniae .Gram-positive pathogens consist of Staphylococcus aureus and Staphylococcus aureus. Different bacteria is isolated in different seasons and regions. The commonly used first-line and second-line antibiotics sensitive rates of bacteria are low, and selecting sensitive antibiotics is the key to effective treatment of neonatal infections.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222456
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
王君棪. 新生儿细菌感染性疾病的病原分布及药敏分析[D]. 兰州. 兰州大学,2013.
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