| 心力衰竭患者血浆脑钠肽水平与左室质量比值的相关性研究 |
| Alternative Title | Correlation between plasma level of brain natriuretic peptide and the ratio of predicted left ventricular mass in patients with congestive heart failure
|
| 王君 |
| Thesis Advisor | 陈天铎
; 李培杰
|
| 2005-05-31
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 心力衰竭
充血性
利钠肽
左室质量比值
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| Abstract | 目的：探讨心力衰竭患者血浆脑钠肽(BNP)﹑肿瘤坏死因子-α(TNF-α)﹑内皮素(ET)的水平及与左室质量比值(%PLM)的相关性 。
方法： 用放射免疫法测定71例心力衰竭患者（CHF组，心功能Ⅱ-Ⅳ级）及30例体检正常者（对照组）血浆BNP、TNF-α和ET的水平；超声心动图测定CHF组及对照组左室质量，并根据收缩压计算左室质量预计值，左室质量比值（%PLM）=左室质量实测值/左室质量预计值。
结果: CHF组的血浆BNP、TNF-α、ET水平及%PLM显著高于对照组 （P<0.01），且BNP、TNF-α、ET水平与%PLM呈正相关，相关系数分别为r=0.79、 P<0.01， r=0.60、P<0.05， r=0.56、 P<0.05。
结论: 心力衰竭患者血浆BNP、TNF-α、ET水平明显增高，反映心室重塑的左室质量比值异常，BNP与左室质量比值相关性最好。 |
| Other Abstract | Objective: To estimate the diagnostic value of the level of plasma brain natriuretic peptide (BNP), tumor necrosis factor (TNF-α), endothelins (ET) in patients with congestive heart failure and the relationship with the ratio of predicted left ventricular mass.
Methods: plasma BNP, TNF-α, ET concentration of patients with CHF group (n=71) and of normal controls (n=30) were measured by radioimmunology assay. Left ventricular mass was measured by echocardiography.
Result: The plasma BNP, TNF-α, ET concentration of patients in CHF group were significantly higher than those of normal controls (p<0.01), they also increased according to the severity of heart failure classified by NYHA classes. The plasma BNP, TNF-α, ET level in CHF group had a positive correlation with %PLM respectively (r=0.79, P<0.01; r=0.60, P<0.05; r=0.56, P<0.05). Moreover, there was a significant positive correlation between the plasma level of BNP and %PLM.
Conclusion: The plasma BNP level was highly associated with the %PLM, it may be a useful biochemical parameter for evaluating the CHF. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/222473
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
王君. 心力衰竭患者血浆脑钠肽水平与左室质量比值的相关性研究[D]. 兰州. 兰州大学,2005.
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