兰州大学机构库 >学院待认领
胃癌组织Ets-1、c-Jun、MMP-9和HER-2的表达及其与临床病理学和生存期的关系
Alternative TitleRelationship between expression of Ets-1、c-Jun、MMP-9、HER-2 in gastric carcinoma and its clinicopathology as well as patient survival
任涛文
Thesis Advisor吴静
2009-05-22
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword胃癌 Ets-1 c-Jun MMP-9 HER-2 临床病理学 生存期
Abstract目的 研究胃癌组织中Ets-1、c-Jun、MMP-9、HER-2蛋白的表达,探讨其表达与临床病理特征及生存期的关系。 方法 189例胃癌手术切除标本、54例癌旁组织及41例胃癌淋巴结制作成组织芯片。32例正常胃粘膜作为对照。应用免疫组织化学S-P法及组织芯片技术检测Ets-1、c-Jun、MMP-9、HER-2蛋白的表达。对有生存资料的101例胃癌患者进行Kaplan-Meier生存分析,并应用Cox比例风险回归模型分析预后因素。 结果 1.胃癌、癌旁和对照组Ets-1阳性表达率分别是71.4%、29.6%和18.8%。三组间的差异具有统计学意义(χ2=51.686,P=0.000)。淋巴结转移组和无淋巴结转移组Ets-1阳性表达率分别为79.3%、58.9%,两组间的差异有统计学意义(χ2=9.142,P=0.002)。浸润未及浆膜组和浸润达浆膜及浆膜以外组Ets-1阳性表达率分别为50.0%、78.3%,两组间的差异有统计学意义(χ2=13.679,P=0.000)。 2.胃癌、癌旁和对照组c-Jun阳性表达率分别是73.0%、25.9%和21.9%。三组间差异具有统计学意义(χ2=53.370,P=0.000)。高/中分化组和低分化组c-Jun阳性表达率为80.9%、66.0%,两组间的差异有统计学意义(χ2=5.305,P=0.021)。 3.胃癌、癌旁和对照组MMP-9阳性表达率分别是78.3%、22.2%和15.6%。三组间的差异具有统计学意义(χ2=84.759,P=0.000))。淋巴结转移组和无淋巴结转移组MMP-9阳性表达率分别为84.5%、68.5%,两组间的差异有统计学意义(χ2=6.743,P=0.009)。浸润未及浆膜组和浸润达浆膜及浆膜以外组MMP-9阳性表达率分别为65.2%、82.5%,两组间的差异有统计学意义(χ2=6.132,P=0.013)。高/中分化组和低分化组MMP-9阳性表达率分别为70.8%、85.0%,两组间的差异有统计学意义(χ2=5.600,P=0.018)。弥漫型胃癌组和肠型胃癌组MMP-9阳性表达率分别为84.7%、72.2%,两组间的差异有统计学意义(χ2=4.155,P=0.042)。 4.胃癌、癌旁和对照组HER-2阳性表达率分别是68.8%、25.9%和12.5%。三组间的差异具有统计学意义((χ2=55.913,P=0.000))。淋巴结转移组和无淋巴结转移组HER-2阳性表达率分别为75.0%、58.9%,两组间的差异有统计学意义(χ2=5.406,P=0.020)。浸润未及浆膜组和浸润达浆膜及浆膜以外组HER-2阳性表达率分别为52.2%、74.1%,两组间的差异有统计学意义(χ2=7.811,P=0.005)。高/中分化组和低分化组HER-2阳性表达率分别为76.4%、62.0%,两组间的差异有统计学意义(χ2=4.550,P=0.033)。弥漫型胃癌组和肠型胃癌组HER-2阳性表达率分别为61.2%、76.3%,两组间的差异有统计学意义(χ2=4.857,P=0.028)。 5.41例淋巴结转移灶和相对应的41例胃癌中的表达:两组间Ets-1阳性表达率分别为84.4%、58.5%,差异具有统计学意义(χ2=7.312,P=0.007)。两组间c-Jun阳性表达率分别为90.2%、78.0%,差异无统计学意义(χ2=2.285,P=0.131))。两组间MMP-9阳性表达率分别为95.2%、80.5%,差异有统计学意义(χ2=4.260,P=0.039)。两组间HER-2阳性表达率分别为87.8%、68.3%,差异有统计学意义(χ2=4.556,P=0.033)。 6. 癌...
Other AbstractObjective: To study the expression of Ets-1、c-Jun、MMP-9、HER-2 in gastric carcinoma and analyze the features of them and the relationship between them with clinicopathology as well as patient prognosis. Methods: 189 cases of gastric carcinoma, 54 cases of paracancer and 41 cases of lymph nodes were made into tissue microarray. Meanwhile 32 cases of normal gastric tissue were chosen as control. Ets-1、c-Jun、MMP-9、HER-2 were detected by immunohistrochemistry staining. Kaplan-Meier survival analysis was performed for 101 cases with survival time. We analyzed the prognostic factors by Cox regression model in these cases. Results: 1.The positive rates for Ets-1of the gastric carcinoma, paracancer and control were respectively 71.4%、29.6% and 18.8%, with significant difference (P < 0.05) among the three case groups. The positive rates for Ets-1 of the positive lymph node metastasis and without lymph node metastasis were 79.3% and 58.9% respectively. There was significant difference between the two groups(χ2=9.142,P=0.002). The positive rates for Ets-1 of the gastric carcinoma with invasion under serosa and that with invasion out of serosa were respectively 50.0% and 78.3%, There was significant difference between the two groups (χ2=13.679,P=0.000). 2.The positive rates for c-Jun of the gastric carcinoma, paracancer and control were respectively 73.0%、25.9% and 21.9%, with significant difference (P < 0.05) among the three case groups. The positives rates for c-Jun of the differentiated gastric carcinoma and undifferentiated gastric carcinoma were 80.9% and 66.0% respectively. There was significant difference between the two groups(χ2=5.305, P=0.021). 3.The positive rates for MMP-9 of the gastric carcinoma, paracancer and control were 78.3%、22.2% and 15.6% respectively, with significant difference among the three case groups(P < 0.05). The positive rates for MMP-9 of the gastric carcinoma with invasion under serosa and that with invasion out of serosa were 65.2% and 82.5%respectively, There was significant difference between the two groups(χ2=6.132,P=0.013). The positive rates for MMP-9 of the gastric carcinoma with lymph node metastasis and that of those without lymph node metastasis were 84.5% and 68.5% respectively, the former was higher than the latter (χ2=6.743,P=0.009). The positives rates for MMP-9 of the differentiated gastric carcinoma and undifferentiated gastric carcinoma were 70.8% and 85.0% res...
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Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222559
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
任涛文. 胃癌组织Ets-1、c-Jun、MMP-9和HER-2的表达及其与临床病理学和生存期的关系[D]. 兰州. 兰州大学,2009.
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