| 胃癌Smad4、CyclinD1、p21waf1表达及其与临床病理特征和生存关系 |
| Alternative Title | The relationship between Smad4,CyclinD1,p21waf1 protein expression and clinicopathology features in gastric carcinoma as well as patient survival
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| 李强 |
| Thesis Advisor | 周永宁
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| 2008-05-23
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 胃癌
Smad4
CyclinD1
p21waf1
临床病理特征
生存期
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| Abstract | 目的：检测Smad4、CyclinD1 和p21waf1在胃癌、癌旁组织及淋巴结的表达状况，分析三者的相关性及与MVD、MLD、临床病理特征、生存期的关系，探讨它们在胃癌的发生发展及浸润转移过程中的作用及可能的机制。
结论： 1 Smad4在胃癌中呈低表达，其表达与分化程度及Lauren分型相关，提示Smad4的表达可能影响到胃癌的分化并与其进展有关；p21waf1在胃癌中的阳性表达率降低，其表达与患者的年龄、分化程度，Lauren分型相关，p21waf1的低表达可能与胃癌的发生发展相关；CyclinD1的在胃癌中呈高表达，和分化程度、Lauren分型及淋巴结转移有关，提示其过表达和肿瘤的发生发展相关联，是胃癌发展过程中的一个早期分子事件。MVD/MLD在胃癌中水平增高，且在胃癌中的水平和其生物学行为密切相关，对胃癌的发生发展有重要的影响。
2 Smad4 和p21waf1蛋白表达呈正相关性，提示可能由于上游的Smad4蛋白的低表达从而导致了其下游的p21waf1蛋白表达水平的下降。MVD和MLD之间呈正相关，二者可互相影响。
3 Smad4阳性表达者其预后优于阴性者，提示Smad4蛋白阳性表达对胃癌患者来说是一个有利的预后因素，但尚不能作为一个独立的预后判断指标。 |
| Other Abstract | Objective To evaluate the expression of Smad4,CyclinD1,p21waf1 protein and MVD, MLD in gastric carcinoma ,cancer-adjacent tissue, lymph nodes and determine the relationship between them and tumor clinicopathological features as well as patient survival.
Conclusions 1 Smad4 expression rate reduces in gastric carcinoma, and its
abnormal expression is related with differentiation and Lauren’s types, this indi-cates that expression of Smad4 influence tumor differentiation; p21waf1 exprssion
reduces in gastric carcinoma, too, and which is correlates with differentiation ,
Lauren’s types and the age. Its abnormal expression may rezult in tumorigenes-is; CyclinD1 appears to be overexpressed in gastric carcinoma, and it is relates
with lymph node metastasis, differentiation and Lauren’s types. MVD/MLD level rises in gastric carcinoma, and the level , which is related with the bio-behaviors of gastric carcinoma closely, affects the tumorigenesis and development of gastric carcinoma greatly.
2 Smad4 is correlates with p21waf1,which indicates that reduced expression of smad4 leads to abnormal expression of its downstream gene p21waf1 .MVD correlates with MLD and, they interact in gastric carcinoma.
3 Survival rate in positive expression of Smad4 surpasses the negative express-ion. Positive expression of Smad4 is a favorable prognostic factor, but not an independent one in patients with gastric carcinoma. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/222580
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
李强. 胃癌Smad4、CyclinD1、p21waf1表达及其与临床病理特征和生存关系[D]. 兰州. 兰州大学,2008.
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