| 头痛宁胶囊联合氟桂利嗪胶囊治疗偏头痛的临床疗效及机理研究 |
| Alternative Title | Clinical effect of Toutongning Capsules combined with Flunarizine Capsules in treatment of migraine
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| 马娟 |
| Thesis Advisor | 刘宁
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| 2013-05-24
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 偏头痛
头痛宁胶囊
视觉模拟评分
血清电解质
5-羟色胺
降钙素基因相关肽
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| Abstract | 目的：观察头痛宁胶囊联合氟桂利嗪胶囊治疗偏头痛的临床疗效及相关因子变化，探讨其改善偏头痛患者头痛的可能作用机制。
方法：选择2011年10月至2012年5月兰州大学第一医院神经内科门诊确诊的偏头痛患者90例，采取随机、对照方法，将90例患者分为3组，即头痛宁组、氟桂利嗪组和两药联合组，治疗28天，观察治疗前后患者视觉模拟评分(VAS)、血清电解质、血浆5-羟色胺(5-HT)及降钙素基因相关肽(CGRP)浓度的变化。
结果：(1) 头痛程度VAS评分显示，用药前三组VAS评分无统计学差异(P>0.05)，用药后三组VAS评分分别不同程度的减低，差异均有统计学意义(P<0.01)；VAS评分减低程度头痛宁组和氟桂利嗪组低于两药联合组，差异有统计学意义(P<0.05)，但单药2组之间差异无统计学意义(P>0.05)。(2)血钾、CGRP浓度降低及血镁离子、5-HT浓度升高，联合组优于头痛宁组与氟桂利嗪组(P<0.05)，头痛宁组与氟桂利嗪组相比差异相当(P>0.05)。(3)三组间不良事件的出现有显著性差异(P<0.05)，头痛宁组与联合组差异相当(P>0.05)。
结论：头痛宁胶囊可以缓解偏头痛患者的头痛程度，其机制可能与降低血清中钾离子浓度，升高镁离子浓度及降低血浆CGRP浓度，升高5-HT浓度有关。且不良事件发生少，患者接受程度高，依从性好。 |
| Other Abstract | Objective: To observe the clinical curative effect of Toutongning Capsules on patients with migraine.
Methord: To select 90 outpatients with migraine,which were diagnosed by department of Neurology.They were all from the First Hospital of Lanzhou University during the period of October 2011 to May 2012. 90 patients with migraine were randomly divided into three groups: Toutongning capsules group,Flunarizine capsules group and Toutongning capsules combined with Flunarizine capsules group. Three groups were treated for 28 days and then the score of Visual Analogue Scale（VAS） were observed. Blood serum electrolytes,plasma 5-hydroxytryptamine(5-HT) and plasma calcitonin gene-related peptide(CGRP) were measured before and after treatment.
Results: Firstly, the scores of VAS were no statistically significant difference of three groups in before treatment(P>0.05), the scores of VAS were decreased in the three groups those in after treatment compared with those before treatment，there was statistically significant differences of all(P<0.01). The scores of VAS of two-drug combination group to reduce better than Toutongning capsule and Flunarizine capsule, there was significant differences(P<0.05), but there was no significant difference between the Toutongning group and Flunarizine group (P>0.05). Secondly, blood level of K+，plasma level of calcitonin gene-related peptideand decreased and blood level of Mg2+ plasma level of 5-hydroxytryptamine advanced. Toutongning capsules combined with Flunarizine capsules group was better than the Toutongning capsules group and the Flunarizine capsules group(P<0.05).There was no significant difference between the Toutongning capsules group and Flunarizine capsules group in the biochemical indicators concentration difference(P>0.05).Thirdly, there was significant differences of adverse events among the three groups(P<0.05) except for between the Toutongning capsules group and Toutongning capsules combined with Flunarizine capsules group (P>0.05).
Conclusion: The Toutongning capsules can relieved in headache without adverse events of patients with migraine, in relation to the decrease in blood level of K+, plasma level of calcitonin gene-related peptideand and the increase in blood level of Mg2+, plasma level of 5-hydroxytryptamine. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/222623
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
马娟. 头痛宁胶囊联合氟桂利嗪胶囊治疗偏头痛的临床疗效及机理研究[D]. 兰州. 兰州大学,2013.
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