兰州大学机构库 >学院待认领
同型半胱氨酸在脓毒症患儿血浆中的表达及其对心肌抑制作用的研究
Alternative TitleThe Homocysteine Expression in The Plasma of Children with Sepsis and its Study of Myocardial Depression
王晋
Thesis Advisor董湘玉
2013-05-16
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword同型半胱氨酸 脓毒症 心肌抑制
Abstract目的:探讨同型半胱氨酸(HCY)在脓毒症患儿血浆中的表达及其对心肌抑制的作用。方法:收集2012年4月至2013年1月入住我院儿科重症监护室的脓毒症患儿88例,根据诊断将患儿分为:脓毒症组49例(55.7%),严重脓毒症组27例(30.1%),脓毒症休克组12例(13.7%),实验组平均年龄(2.27±2.76)岁。纳入标准完全按照2005年国际脓毒症标准。选取同期儿童保健门诊健康体检儿童35例为对照组,平均年龄(2.40±3.35)岁。患儿血浆中同型半胱氨酸采用生物素双抗体夹心酶联免疫法检测,同时测量CRP、CK-MB 、cTnI作比较。结果:(1)正常患儿血浆中同型半胱氨酸为(3.86±1.41)μmol/L,与实验组比较,同型半胱氨酸水平具有统计学意义(p<0.05);(2)实验组中患儿的血浆HCY在脓毒症组、严重脓毒症组、脓毒症休克组中相比,均有明显的升高,各组间有统计学意义(p<0.05);(3)血浆HCY明显升高时,cTnI也明显升高。同型半胱氨酸与cTnI做相关性分析(r=0.279,p<0.05),有正相关性。结论:(1)血浆中同型半胱氨酸对判断脓毒症心肌受累的程度及预后有重要意义;(2)血浆中同型半胱氨酸含量的增加与心肌抑制密切相关,高同型半胱氨酸血症是脓毒症合并心肌抑制的高危险因素之一,检测同型半胱氨酸含量对诊断和防治心肌抑制有重要的临床意义。
Other AbstractObjective: To investigate the expression of homocysteine in the blood plasma of children with sepsis and its effect on septic myocardial dysfunction.Methods: from April 2012 to January 2013 to stay in PICU of Lanzhou University Second Hospital, 29-days to 16-year-old children with sepsis 88 cases, and divided into: 49 of sepsis group (55.7%), 27 cases of severe sepsis group (30.1%), 12 cases of septic shock group(13.7%),the average age of (2.27±2.76) years . Selected 35cases of healthy children as a control group ,the average age of (2.40 ± 3.35) years. Enzyme linked immunosorbent assay-sandwich technique was detected each group of children with plasma HCY concentration, and compared with CRP, CK-MB, cTnI. Results: (1) Normal children with plasma homocysteine (3.86±1.41) μmol/L, compared with the experimental group, HCY levels was statistically significant (p<0.05). (2) Plasma HCY in children compared with sepsis, severe sepsis and septic shock in children were significantly higher(p<0.05); (3) Elevated plasma HCY, cTnI significantly increased.HCY and cTnI correlation analysis (r=0.279, p<0.05).Conclusion: (1) HCY important to judge the severity and prognosis of myocardial depression; (2) Plasma HCY levels increase are closely related to the myocardial depression of sepsis.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222628
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
王晋. 同型半胱氨酸在脓毒症患儿血浆中的表达及其对心肌抑制作用的研究[D]. 兰州. 兰州大学,2013.
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