|Alternative Title||The Evidence-based Study of TMZ vs Traditional Chemotherapy Drugs to Treatment High Grade Glioma
|Place of Conferral||兰州
|Abstract||目的 本研究在对替莫唑胺（Temozolomide, TMZ）与传统化疗药治疗高级别脑胶质瘤的有效性和安全性进行系统评价的基础上，利用历史性队列研究方法收集TMZ方案和传统化疗药替尼泊苷联合顺铂方案治疗高级别脑胶质瘤的临床资料，分析比较两组药物临床疗效，从而为临床决策提供证据参考。
|Other Abstract||Objective Based on the systematic review, using the historical cohort way research the two groups and do statistic analysis on the data. This study would provide the evidence of EBM in clinical practice for TMZ vs VM-26+DDP to treat high grade glioma.
Methods The literatures of randomized controlled trials comparing temozolomide with traditional chemotherapy drugs for glioma patients were retrieved by searching Databases from their inception date to Dec 2013. Two researchers independently screened literatures according to the predefined inclusion and exclusion criteria, extracted data, and assessed the methodological quality of included studies. Meta-analysis was performed by using RevMan 5.2 software. Using the historical cohort way objectively evaluate the curative and untoward effect and economics of TMZ vs VM-26+DDP on glioma.
Results A total of 8 RCTs involving 864 patients were finally selected, with 374 cases in TMZ group and 490 cases in traditional chemotherapy drugs group. The baseline data of each trial were preferably comparable. The results of meta-analyses showed that the therapy effective rate, five-year survival rate, the progression-free survival, the average survival were significantly increased in TMZ group compared with traditional chemotherapy drugs group for the treatment of glioma patients of postoperative radiotherapy (all P<0.05). And alimentary tract reactions, marrow depression were significantly reduced in TMZ group compared with traditional chemotherapy drugs group for the treatment of glioma patients. The historical cohort proved the curative effect and safety have no difference between two groups. Moreover, economic evaluation showed TMZ group costed higher than VP group.
Conclusions Compared with traditional chemotherapy drugs, TMZ is safe and reliable with better overall curative effect, less adverse reactions and prolonged survival time for glioma patients of postoperative radiotherapy. Current available evidence demonstrated the curative effect in TMZ and VP is similar, however, TMZ costs higher than VP.|
田宏亮. 替莫唑胺对比传统化疗药治疗高级别脑 胶质瘤的循证研究[D]. 兰州. 兰州大学,2014.
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