| 适用于血流动力学研究的犬肾下腹主动脉假性动脉瘤模型的建立 | |
| Alternative Title | Establishment of hemodynamic study in canine infrarenal abdominal aortic pseudo-aneurysm model |
| 宋润泽 | |
| Subtype | 硕士 |
| Thesis Advisor | 杨永珠 |
| 2013-05-23 | |
| Degree Grantor | 兰州大学 |
| Place of Conferral | 兰州 |
| Degree Name | 硕士 |
| Keyword | 主动脉瘤 腹 疾病模型 犬 动物 |
| Abstract | 背景：腹主动脉瘤（abdominal aortic aneurysm，AAA）指腹主动脉局限性退化扩张至超过正常腹主动脉直径的1.5倍以上。AAA有自然破裂的风险，据估计约一半以上的AAA在未到医院诊治之前已破裂死亡，90%以上的破裂者发生猝死。因而AAA是严重危害患者生命的重大血管疾病。构建腹主动脉假性动脉瘤动物模型，评估其形态学和血流动力学具有重要现实和指导意义。 20世纪90年代初，Parodi首先在国际上开展了微创的腔内隔绝术（endvascular graft exclusion，EVGE），用于治疗AAA。我国于1997年也已成功开展了此类手术。与传统手术相比，其微创特色明显降低了其并发症及死亡率。M.henry于2008年首先使用多层裸支架治疗肾动脉瘤，并取得了很好疗效。为了研究犬肾下腹主动脉假性动脉瘤多层裸支架隔绝动脉瘤后瘤腔内血液动力学变化的研究。我们构建了牛颈静脉替代比格犬腹主动脉构建肾下腹主动脉假性动脉瘤模型。 目的：建立适用于血液动力学研究的犬肾下腹主动脉假性动脉瘤模型，并进行形态学及血液动力学评估。 方法：选取健康雌性比格犬14只，其中7只采取传统静脉补片方法建立假性动脉瘤作为对照组，另外7只采取新的“袋状”静脉补片方法建立假性动脉瘤模型作为实验组。并于术后即刻、7天、14天及30天进行CTA检查，术后7天进行彩超检查，对其进行形态学及血液动力学评估。 结果：实验动物存活率100%。采取传统静脉补片法建立的模型在术后即刻、7天、14天、30天时局部管壁扩张率分别为（6.11±2.38）%、（26.14±7.14）%、(63.42±12.77)%、（88.26±14.42）%，采取“袋状”静脉补片法建立的模型在术后即刻、7天、14天、30天时局部管壁扩张率分别为（199.39±14.92）%、（216.83±14.68）%、（239.30±16.75）%（266.30±16.48）%。在各观测点上，实验组较对照组管壁扩张率高，其差异有统计学意义。 结论：采取“袋状”静脉补片法建立的犬肾下腹主动脉假性动脉瘤的模型在形态学及血液动力学方面更加符合人体假性动脉瘤的特点，适合于多层裸支架隔绝动脉瘤后瘤腔内血液动力学变化的研究。 |
| Other Abstract | Background: Abdominal aortic aneurysm is the abdominal aortic limitations degradation expansion to more than 1.5 times of the normal diameter. AAA naturally the risk of rupture, it was estimated that more than about half of the AAA before yet reached the hospital for treatment has been ruptured death, more than 90% of the rupture to sudden death. Therefore, AAA is seriously endanger the patient's life major vascular disease. It has important practical significance that build infrarenal abdominal aortic aneurysm animal model to evaluate the morphological and hemodynamic. The early 1990s, Parodi first carried out in the international minimally invasive endovascular graft exclusion for the treatment of the AAA. China in 1997 has been successfully carried out this type of surgery. Compared with traditional surgery, minimally invasive characteristics significantly reduce morbidity and mortality. In 2008, M.henry the first to use the multi-storey bare stent treatment of renal artery aneurysms and made a good effect. In order to study canine renal abdominal aortic pseudo aneurysm multilayer bare stent isolate the aneurysm endovascular hemodynamic change research. We build abdominal aortic pseudo aneurysm model for the bovine jugular alternative beagles abdominal aortic. Objective: To establish the hemodynamic study in canine infrarenal abdominal aortic pseudo aneurysm tumor model, and the morphologic and hemodynamic assessment. Methods: Select female beagle dogs 14, seven of which take the traditional vein patch the establishment of a pseudo-aneurysm as a control group, the other seven to take the new "pocket" vein patch pseudo aneurysm model as the experimental group. And after 7 days, 14 days and 30 days to carry out the color Doppler ultrasound, CTA examination, their morphologic and hemodynamic assessment. Result: Experimental animal survival rate of 100%. The local wall expansion rate, take the model of the traditional vein patch was established in the immediate postoperative period, 7 days, 14 days, 30 days, respectively (6.11 ± 2.38)% (26.14 ± 7.14)% (63.42 ± 12.77)% (88.26 ± 14.42)%, adopt a "pocket" vein patch method to establish the model in the immediate postoperative 7 days, 14 days, 30 days, respectively (199.39 ± 14.92)% (216.83 ± 14.68 )%, (239.30 ± 16.75)% (266.30 ± 16.48)%. Each observation point, the experimental group and control group wall expansion rate, the difference was statistically significant. Conclusion: Adopt a "pocket" ... |
| URL | 查看原文 |
| Language | 中文 |
| Document Type | 学位论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/222699 |
| Collection | 学院待认领 |
| Affiliation | 临床医学院 |
| Recommended Citation GB/T 7714 | 宋润泽. 适用于血流动力学研究的犬肾下腹主动脉假性动脉瘤模型的建立[D]. 兰州. 兰州大学,2013. |
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