| 食管癌组织中STAT3和P38的表达及临床意义的研究 |
| Alternative Title | Expression and clinical significance of STAT3 and p38 in esophageal carcinoma
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| 孙莹 |
| Thesis Advisor | 卢启明
|
| 2012-05-18
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 食管癌
信号转导和转录激活因子3
P38
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| Abstract | 目的: 通过检测食管鳞癌和腺癌组织中STAT3（signal transducers and activators of transcription 3）和P38的表达,了解STAT3和P38的表达及其与食管癌临床和病理的关系；探讨STAT3和P38 的相互关系；探讨二者的表达与食管癌组织的浸润深度，淋巴结转移的关系；为临床抗肿瘤治疗寻找新的途径。 结论： STAT3和P38参与了肿瘤的进展，在食管癌的发生发展中起重要作用,其表达上调在一定程度上可以预测肿瘤恶性程度，对指导临床治疗和判断预后及生存期有一定帮助。二者在食管鳞癌和腺癌组织中的表达无差异。 |
| Other Abstract | OBJECTIVE: To investigate STAT3 and P38 protein expressions in human esophageal carcinoma,and analyze the clinical significance in development and prognosis of esophageal carcinoma. METHODS: Immunohistochemical was used to determine the expression of STAT3 and P38 protein in 89 case of esophageal carcinoma tissues and 20 case of corresponding normal tissues. RESULTS: The expression of STAT3 and P38 protein in esophageal carcinoma cell were significantly higher than those in normal esophageal epithelium（P<0.05）. The expression of the 2 proteins were positively correlated with lymph node metastasis(r=0.242,0.249 respectively), and negatively correlated with degree of differentiation(r=-0.395,-0.389 respectively) ,but not with years, gender ,types and site (P＞0.05) . COMCLUSION: The trial suggested that stat3 and p38 play a critical role in the carcinogenesis of the esophagus and contribute to judge the malignancy degree and prognosis. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/222706
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
孙莹. 食管癌组织中STAT3和P38的表达及临床意义的研究[D]. 兰州. 兰州大学,2012.
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