| 青光眼患者房水中β淀粉样蛋白的检测 |
| Alternative Title | Measurement of β Amyloid Protein in Aqueous Humor of Glaucomatous Eyes
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| 周金子 |
| Thesis Advisor | 鲁建华
; 张文芳
|
| 2005-05-31
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 青光眼
白内障
β淀粉样蛋白
房水
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| Abstract | 目的：通过检测房水中β淀粉样蛋白（β-AP）的含量，对青光眼的发病机理进行探讨。
方法：用放射免疫分析法(RIA)检测临床诊断为青光眼的患者25例，白内障对照者27例房水中β-AP的水平。
结果：青光眼组β-AP的含量为1.62～5.56pg/ml,平均3.054 0±1.082 8pg/ml;白内障组含量为1.21～5.37pg/ml,平均2.366 7±1.106 7pg/ml,两组差异有统计学意义(t=2.261,P＜0.05)。青光眼组患者房水中β-AP含量与病程之间无相关关系（r=–0.104,P＞0.05）。
结论：青光眼患者房水中β-AP水平明显高于白内障对照组，并与病程长短无关。青光眼可能是一种神经细胞变性性疾病。 |
| Other Abstract | Objective ：To assess the role of β amyloid protein in the pathophysiology of glaucoma by measuring the concentration of β amyloid protein in the aqueous humor of glaucoma patients.
Methods ： β-AP levels were measured by radioimmunoassay method with antibody against β-AP in glaucoma and cataract groups.
Results ： The values of β-AP for glaucoma patients were 1.62～5.56pg/ml with mean value of 3.054 0±1.082 8 pg/ml. In cataract group, the values of β-AP were 1.21～ 5.37pg/ml with mean of 2.366 7±1.106 7pg/ml. The mean value for glaucoma was significantly different from that of the cataract group. The β-AP level was not correlated with duration of glaucoma .
Conclutions： β-AP level in aqueous humor of glaucoma was significanfly higher than that in cataract group. It did not correlate with duration of glaucoma symptoms. Glaucoma might be a degenerative disease of retinal ganglion cells. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/222849
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
周金子. 青光眼患者房水中β淀粉样蛋白的检测[D]. 兰州. 兰州大学,2005.
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