兰州大学机构库 >学院待认领
青光眼患者房水中β淀粉样蛋白的检测
Alternative TitleMeasurement of β Amyloid Protein in Aqueous Humor of Glaucomatous Eyes
周金子
Thesis Advisor鲁建华 ; 张文芳
2005-05-31
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword青光眼 白内障 β淀粉样蛋白 房水
Abstract目的:通过检测房水中β淀粉样蛋白(β-AP)的含量,对青光眼的发病机理进行探讨。 方法:用放射免疫分析法(RIA)检测临床诊断为青光眼的患者25例,白内障对照者27例房水中β-AP的水平。 结果:青光眼组β-AP的含量为1.62~5.56pg/ml,平均3.054 0±1.082 8pg/ml;白内障组含量为1.21~5.37pg/ml,平均2.366 7±1.106 7pg/ml,两组差异有统计学意义(t=2.261,P<0.05)。青光眼组患者房水中β-AP含量与病程之间无相关关系(r=–0.104,P>0.05)。 结论:青光眼患者房水中β-AP水平明显高于白内障对照组,并与病程长短无关。青光眼可能是一种神经细胞变性性疾病。
Other AbstractObjective :To assess the role of β amyloid protein in the pathophysiology of glaucoma by measuring the concentration of β amyloid protein in the aqueous humor of glaucoma patients. Methods : β-AP levels were measured by radioimmunoassay method with antibody against β-AP in glaucoma and cataract groups. Results : The values of β-AP for glaucoma patients were 1.62~5.56pg/ml with mean value of 3.054 0±1.082 8 pg/ml. In cataract group, the values of β-AP were 1.21~ 5.37pg/ml with mean of 2.366 7±1.106 7pg/ml. The mean value for glaucoma was significantly different from that of the cataract group. The β-AP level was not correlated with duration of glaucoma . Conclutions: β-AP level in aqueous humor of glaucoma was significanfly higher than that in cataract group. It did not correlate with duration of glaucoma symptoms. Glaucoma might be a degenerative disease of retinal ganglion cells.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222849
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
周金子. 青光眼患者房水中β淀粉样蛋白的检测[D]. 兰州. 兰州大学,2005.
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