兰州大学机构库 >学院待认领
内脂素基因多态性与甘肃地区汉族人群2型糖尿病的相关性
Alternative TitleThe association of single nucleotide polymorphism of visfatin gene with type 2 diabetes in GanSu Han population
张文博
Thesis Advisor田林红
2009-05-31
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword内脂素 2型糖尿病 基因多态性
Abstract目的 探讨甘肃地区汉族人中内脂素基因启动区域rs2110385和rs17373587的变异与2型糖尿病(type 2 diabetes mellitus,T2DM)的关联。 方法 随机选取无亲缘关系甘肃地区汉族人188名,其中T2DM患者104例、正常对照84名,应用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)方法进行rs2110385和rs17373587变异的检测。 结果 正常对照组rs2110385的3种基因型频率和等位基因频率分别为GG 78.6%、GT 14.3%、TT 7.1%、G85.7%、T 14.3%,2型糖尿病组相应为GG 67.3%、GT15.4%、TT 17.3%、G 75.0%、T 25.0%,2型糖尿病组TT基因型频率和T等位基因频率高于正常对照组(χ2=4.315, P<0.05;χ2=6.621, P<0.05)。rs17373587处3种基因型频率和等位基因频率差异无统计学意义。在T2DM组中rs2110385和rs17373587的三种基因型与体质指数、收缩压、舒张压、总甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖的差异无统计学意义(P>0.05)。 结论 提示内脂素基因rs2110385多态性可能与中国汉族人2型糖尿病有关联。
Other AbstractObjective To determine the association of the promoter of visfatin gene and the susceptibility of type 2 diabetes mellitus in Chinese Han population. Methods  A total of 188 unrelated subjects, including 104 type 2 diabetes and 84 normal glucose tolerant (NGT) controls,were recruited. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were employed to screen the polymorphism. Results In the normal glucose tolerant control group,the genotype frequencies and allele frequencies of rs2110385 were GG78.6%, GT14.3%,TT7.1%, G85.7%, T14.3%, while the corresponding frequencies in the type 2 diabetes group were GG67.3%, GT15.4%, TT17.3%, G75.0%, T25.0% respectively,the TT genotype frequency and T allele frequency of type 2 diabetes was higher than that of normal glucose tolerant control (χ2=4.315,P<0.05;χ2=6.621,P<0.05). No differences were found in the genotype frequencies and allele frequencies of rs17373587. In the type 2 diabetes group,the variant did not associate with levels of body mass index(BMI), SBP, DBP, TG,TC, HDL, LDL, FBG. (P>0.05). Conclusion The above results suggest that the rs2110385 polymorphism of visfatin gene maybe correlate with type 2 diabetes in Chinese Han population.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/222923
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
张文博. 内脂素基因多态性与甘肃地区汉族人群2型糖尿病的相关性[D]. 兰州. 兰州大学,2009.
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