兰州大学机构库 >学院待认领
邻苯二甲酸二丁酯(DBP)与2型糖尿病相关性研究
Alternative Titlestudy on the association of di-n-butyl phthalate (DBP) level with type 2 diabetes
王正
Thesis Advisor何继瑞
2015-05-21
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword邻苯二甲酸二丁酯 2型糖尿病 环境内分泌干扰物
Abstract目的 通过对糖尿病患者与正常对照组人群中血清及尿液中邻苯二甲酸二丁酯(DBP)水平差异的研究,探讨塑化剂中DBP与2型糖尿病的相关性。 方法 运用酶联免疫吸附实验(ELISA)测定45例初诊2型糖尿病患者与45例正常对照组人群中血清及尿液中DBP水平,并与年龄、性别进行相关性分析。 结果 1、初诊2型糖尿病组血清DBP平均水平为1.693±0.273ppm,尿液中DBP平均水平为0.530±0.275ppm;而正常对照组人群中血清DBP平均水平为1.432±0.129ppm,尿液中DBP平均水平为0.535±0.196ppm。初诊2型糖尿病组患者与正常对照组人群血清DBP浓度,2型糖尿病组中DBP水平均高于正常对照组人群(P<0.05),差异有明显统计学意义;初诊2型糖尿病组患者与正常对照组人群尿液中DBP浓度显示,初诊2型糖尿病组中DBP含量与正常对照组人群组无明显差异(P>0.05),差异无统计学意义。 2、检测样本中邻苯二甲酸二丁酯与初诊2型糖尿病血清浓度的差异,与年龄、性别无明显的相关性。 结论 发现血清中塑化剂邻苯二甲酸二丁酯(DBP)的含量与初诊2型糖尿病的发病有明显相关,推测外源性化学物质的持续刺激参与了糖尿病的发生发展,DBP可能作为2型糖尿病的一个致病因素,为进一步阐述和讨论2型糖尿病在外源性化学物质刺激下的发病机制提供一个实验依据。
Other AbstractObjective To determine the level of DBP in the serum and urine of type 2 diabetes patients and Normal control group difference, explore the relationships between one of plasticizer DBP and type 2 diabetes. Method The concentrations of DBP in serum and urine of 45 type 2 diabetes patients and 45 normal people without diabetes were measured by ELISA determination and then did correlation analysis between them, and analyzed the correlation of age, sex. Results 1. Compare with constituent ratio between diabetes patients and non-diabetic group of DBP content in serum, the composition in diabetes group were higher than in people without diabetes group. 2.The differences in the concentration of serum with phthalic acid dibutyl and type 2 diabetes, there was no obvious correlation with age, sex in the test sample. Conclusion The findings in this cross-sectional study showed that there are high relationship between the level of DBP pollution concentration and the diabetes patients'''' serum is serious than non-diabetic ones, that demonstrate the stimulation of exogenous chemicals involved in the development of diabetes.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223056
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
王正. 邻苯二甲酸二丁酯(DBP)与2型糖尿病相关性研究[D]. 兰州. 兰州大学,2015.
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