| 兰州市1月～36月住院婴幼儿维生素D营养状况及其影响因素 |
| Alternative Title | Vitamin D status and the relative factors of 1 to 36 month infants and toddlers hospitalized in Lanzhou
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| 杨慧 |
| Thesis Advisor | 李宇宁
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| 2013-05-11
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 维生素 D
补充
婴幼儿
缺乏
营养
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| Abstract | 目的 研究兰州市住院婴幼儿维生素D营养状况及其相关影响因素，为评价婴幼儿维生素D营养状况及合理补充维生素D提供依据。
方法 以血清25-羟维生素D水平作为反映维生素D营养状况的指标。采用液相色谱串联质谱法(liquid chromatography–tandem mass spectrometry LC-MS-MS)检测兰州市374名1月～36月住院婴幼儿血清25-羟维生素D浓度，应用维生素D外部质量评估方案(Vitamin D External Quality Assessment Scheme DEQAS)对检验方法进行质量控制。调查维生素D缺乏的相关因素，应用多元线性回归及Logistic回归进行关联性和相关影响因素分析。
结果 ①兰州市1月～36月住院婴幼儿血清25-羟维生素D水平为（30.40±14.88）ng·ml-1<上标!>，19.5％的婴幼儿血清25-羟维生素D水平<20 ng·ml-1<上标!>，即使近期补充过维生素D，仍有3.4％的婴幼儿维生素D缺乏。②血清25-羟维生素D水平有明显季节差异（P=0.04），春季最低，29％的婴幼儿血清25-羟维生素D水平<20 ng·ml-1<上标!>；秋季最好，仍有13％的婴幼儿血清25-羟维生素D水平<20 ng·ml-1<上标!>。③≤6月婴儿维生素D缺乏严重[OR值3.668（95％CI：1.251,10.757）]。6月内纯母乳喂养儿和部分母乳喂养儿较配方奶喂养儿更易出现维生素D缺乏[OR值分别是40.941（95％CI：5.074,330.361），12.211（95％CI：1.411,105.651）]。④补充维生素D及户外活动与血清25-羟维生素D水平呈正相关 [标准化回归系数（β′）分别为0.208（95％CI：1.915,5.276），0.159（95％CI：1.474,6.107）]。未补充维生素D是其缺乏的危险因素[OR值5.211（95％CI：2.476,10.966）]。
结论 兰州市≤6月住院婴儿是维生素D缺乏的高危人群；在春季兰州市住院婴幼儿血清25-羟维生素D水平最低，因此冬春季应加强婴幼儿维生素D的补充；补充维生素D和户外活动与血清25-羟维生素D水平呈正相关，应鼓励婴幼儿坚持户外活动及补充维生素D。兰州市1月～36月住院婴幼儿维生素D营养状况有待改善。 |
| Other Abstract | Objective To study vitamin D status of infants and toddlers hospitalized in Lanzhou and it’s relative factors in order to offer the trend of vitamin D deficiency and the evidence for supplying vitamin D reasonably.
Method The level of serum 25-dihydroxyvitamin D was seen as an indicator of the vitamin D status. Serum 25-dihydroxyvitamin D levels were measured by liquid chromatography–tandem mass spectrometry (LC-MS-MS). We recruited 374 inpatient infants and toddlers that aged of 1 to 36 month in Lanzhou( 36°03 N latitude). We participated Vitamin D External Quality Assessment Scheme（DEQAS） to detect the bias of 25-dihydroxyvitamin D test in our laboratory. Multiple linear regression analysis and logistic regression was used to analyze potential relative factors of vitamin D deficiency which surveyed by a questionnaire.
Result ①The levels of serum 25-dihydroxyvitamin D of infants and toddlers hospitalized in Lanzhou was（30.40±14.88）ng·ml-1<上标!>. The prevalence of vitamin D deficiency was based on the proposed definition of <20ng·ml-1<上标!>. Serum 25-dihydroxyvitamin D <20ng·ml-1<上标!> was shown in 19.5% of infants and toddlers. There were still 3.4% of infants and toddlers with vitamin D deficiency even though they had taken vitamin D supplements recently. ②25-dihydroxyvitamin D levels varied with season(P=0.04).Vitamin D levels was the lowest in spring, with the 25-dihydroxyvitamin D concentration <20 ng·ml-1<上标!> in 29％ of participants. The highest vitamin D level was presented in fall ,but there were still 13％ of participants with 25-dihydroxyvitamin D <20 ng·ml-1<上标!>. ③Many infants under 6 months were lack of vitamin D seriously [OR=3.668（95％CI：1.251,10.757）]. Compared with infants <6 months who were fed with formula, pure breastfeeding and mixed feeding trend to appear to be vitamin D deficiency [OR =40.941（95％CI：5.074,330.361），12.211（95％CI：1.411,105.651）]. ④The 25-dihydroxyvitamin D concentration was positively correlated with vitamin D supplementation and time spent outside [relation coefficient（β′）0.208（95％CI：1.915,5.276），0.159（95％CI：1.474,6.107）respectively]. No taking vitamin D supplementation was significantly associated with an increased risk of deficiency [OR=5.211（95％CI：2.476，10.966）].
Conclusion Infants under 6 months was the high risk group of vitamin D deficiency hospitalized in Lanzhou. Serum 25-dihydroxyvitamin D levels was the lowest in... |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/223095
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
杨慧. 兰州市1月～36月住院婴幼儿维生素D营养状况及其影响因素[D]. 兰州. 兰州大学,2013.
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