兰州大学机构库 >学院待认领
降糖药物与2型糖尿病低血糖的相关性
Alternative TitleStudy on the correlation of hypoglycemic agents anStudy on the correlation of hypoglycemic agents and hypoglycema in type 2 diabetes mellitusd hypoglycema in type 2 diabetes mellitus
李亚聪
Thesis Advisor何继瑞
2013-05-21
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword2型糖尿病 低血糖 降糖药物
Abstract目的 调查实践中2型糖尿病患者使用降糖药物的情况与低血糖事件发生的相关性。方法 回顾总结兰州大学第二医院VIP糖尿病科2型糖尿病合并药物性低血糖患者的病例资料,对150例研究对象进行分析,收集了性别、年龄、降糖药物的使用情况等数据,对收集的相关变量先进行单因素卡方检验,再将上述因素进行多因素Logistic回归分析。 结果 入选的150名2型糖尿病患者,男78例,女72例,年龄(32-78岁),平均年龄64.53±12.93岁。糖尿病患者在治疗过程中低血糖发生率约24%,其中药物相关性低血糖为17%。联合用药的情况:单一用药占30%,联合用药占70%。其中单用降糖药物占药物性低血糖的发生率依次为:胰岛素(11%)、磺脲类(11%)、中药类(9%);2联、3联、4联用药分别占药物性低血糖的比例为40%、29%、1%。单因素分析结果显示有差异的变量是单用胰岛素、联合用药种类,多因素Logistic回归分析结果显示2型糖尿病患者低血糖的发生与单用胰岛素及联合用药的种类有关系。 结论 1.不同年龄组的2型糖尿病患者发生药物性低血糖与单用胰岛素及降糖药物的联合用药种类密切相关。2. 2型糖尿病患者应用降糖药物低血糖发生率仍较高,低血糖发生的主要危险因素为:高龄患者及联合应用多种降糖药,特别是包含胰岛素、磺脲类和中药类药物的联合用药。
Other AbstractObjective The aim of this study was to explore the correlation of hypoglycemic agents and hypoglycema in type 2 diabetic patients. Methods on 150 pairs of subjects which were observed in the second affiliated hospital of Lanzhou medical university. Information was including gender, age, hypoglycemic agents etc. Chi-square test was used to analyze count data on univariate analysis.Stepwise regressive multifactor analysis was performed on above factors. Results In 150 patients with diabetes, male is 78 cases, female is 72 cases, and their mean age was 64.53±12.93 years. In the treatment of patients with diabetes in the incidence of hypoglycemia about 24%, of which 17% drug-related hypoglycemia.Combined treatment: a single drug combination therapy of 30%, Combined treatment accounted for 70% . The use of oral glucose-lowering drugs drug resistance the incidence of hypoglycemia is as follows: the insulin (11%), sulfonylureas (11%), traditional Chinese medicine class (9%); 2 group, 3 group, 4 group was 40%, 29% and 1% respectively.Through univariate conditional Chi-square test,hypoglycemia in type 2 diabetes significantly Association with insulin, combined treatment (P<0.05).The results of multivariate logistic analysis showed that insulin, combined treatment (P<0.05)were still related to hypoglycemia in type 2 diabetes.Conclusions 1.Insulin, combined treatment (P<0.05)are the reversely associated wih thte developmnet of hypoglycemia in type 2 diabetes.2. In patients with type 2 diabetes incidence of hypoglycemia application oral glucose-lowering drugs is still high, low the main risk factors for: elderly patients and the combined use of a variety of diabetes, especially include insulin, sulfonylureas and Chinese medicine drugs combined treatment.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223222
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
李亚聪. 降糖药物与2型糖尿病低血糖的相关性[D]. 兰州. 兰州大学,2013.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[李亚聪]'s Articles
Baidu academic
Similar articles in Baidu academic
[李亚聪]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[李亚聪]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.