|Alternative Title||A systematic review of talc compared with bleomycin for patient with malignant pleural effusion
|Place of Conferral||兰州
结果：6篇随机对照试验研究纳入分析，共224例研究对象。4篇文献质量B级，2篇文献质量C级。分析结果表明：滑石粉治疗恶性胸腔积液在有效率[RR=1.22, 95%CI (1.05, 1.42) ]、复发率[RR=0.31, 95%CI (0.11, 0.87 ]方面优于博来霉素，差异有统计学意义。而在病死率[RR=1.39, 95%CI (0.84, 2.30) ]、发热[RR=0.68, 95%CI(0.24, 1.94]、疼痛[RR=0.22, 95%CI(0.01, 4.32]方面二者差异无统计学意义。
|Other Abstract||Abstract Malignant pleural effusion are a common complication in advanced malignancy. talc, bleomycin and the tetracyclines are the three most frequently used effect. We want to evaluate the efficacy and adverse effect of patients with malignant pleural effusion treated with talc and bleomycin.
Methods We searched PubMed, Embase, The Cochrane Library, Chinese biomedicine literature Database (CBM), CNKI, VIP, reference of included studies for Randomized Controlled Trials comparing talc with bleomycin for patients with malignant pleural effusion. The quality of included studies was assessed independently by two reviewer, discrepancies were resolved by discussion with the third person. We analyzed the Data using Review Manager (version 5.0) software.
Results six studies totaling 224 patients were included. Meta analysis results were as follows: there was significant difference in treatment success [RR=1.22, 95%CI (1.05, 1.42) ]、recurrence rate [RR=0.31, 95%CI (0.11, 0.87 ]between talc group and bleomycin group， there was no significant difference between the two groups in case fatality rate [RR=1.39, 95%CI (0.84, 2.30) ]、fever [RR=0.68, 95%CI (0.24, 1.94]、pain [RR=0.22, 95%CI (0.01, 4.32].
Conclusion Current evidence indicate that talc is super to bleomycin for patients with malignant pleural effusion in terms of improving treatment success and reducing recurrence rate, there is no significant difference between the two group with regard to case fatality rate、fever、pain，the results mentioned above still need to be confirmed by high quality, large sample, multicenter randomized controlled trial.|
魏永罡. 滑石粉和博来霉素治疗恶性胸腔积液的系统评价[D]. 兰州. 兰州大学,2009.
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