红景天苷抗肝纤维化：涉及ROS相关的TGF-β1，NF-κB，MMPs/TIMPs及NO通路

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	红景天苷抗肝纤维化：涉及ROS相关的TGF-β1，NF-κB，MMPs/TIMPs及NO通路
Alternative Title	Salidroside Anti Hepatic Fibrosis: Involves ROS-related TGF-β1, NF-κB, MMPs / TIMPs  and NO pathway
	陈磊
Thesis Advisor	曹农
	2013-05-23
Degree Grantor	兰州大学
Place of Conferral	兰州
Degree Name	硕士
Keyword	红景天苷肝纤维化 ROS HSCs-T6 信号通路
Abstract	观察红景天苷（Salidroside, Sal）对肝纤维化的作用，并探讨其对ROS相关的TGF-β1、MMP-TIMP、NF-κB通路的影响。Sal具有明显的抗肝纤维化作用，其作用机制涉及ROS相关的TGF-β1、MPP/TIMP、NF-κB通路。观察红景天苷（Salidroside, Sal）对大鼠肝星状细胞（hepatic stellate cell , HSCs）-T6增殖的影响，并探讨一氧化氮（NO）在此过程中的作用。Sal对HSCs-T6细胞的增殖具有浓度依赖性的抑制作用，可能是通过NO途径抑制增殖。
Other Abstract	To observe the effect of salidroside on liver fibrosis, and investigate the influence of ROS-related pathways involve TGF-β1, NF-kB, MMPs/TIMPs .Sal has obvious anti liver fibrosis effect,its mechanism of action involves the ROS related TGF - beta 1, MPP/TIMP, the NF-κB pathway. To investigate the effect of Salidroside on proliferation of hepatic stellate Cells(HSCs) and estimate the function of the NO during the procedure.Sal could inhibit the proliferation of HSC-T6.which could be mediated by NO partially at least.
URL	查看原文
Language	中文
Document Type	学位论文
Identifier	https://ir.lzu.edu.cn/handle/262010/223337
Collection	学院待认领
Affiliation	临床医学院
Recommended Citation GB/T 7714	陈磊. 红景天苷抗肝纤维化：涉及ROS相关的TGF-β1，NF-κB，MMPs/TIMPs及NO通路[D]. 兰州. 兰州大学,2013.

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