| 孤立性肺结节的64层螺旋CT灌注成像技术及其应用价值 |
| Alternative Title | The value of 64-slice spiral CT perfusion imaging in solitary pulmonary nodule
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| 张晓军 |
| Thesis Advisor | 周怀琪
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| 2008-05-23
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 孤立性肺结节
灌注
体层摄影术
X线计算机
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| Abstract | 目的 探讨64层螺旋CT灌注成像技术及其在孤立性肺结节诊断和鉴别诊断中的应用价值。
方法 前瞻性利用西门子SOMATOM sensation 64层螺旋CT机对35例孤立性肺结节进行灌注扫描，经随机软件syngo BODY PCT测定孤立性肺结节的灌注参数血容量(blood volume，BV)、血流量(blood flow，BF)、渗透性(permeability，P)的数值以及时间-密度曲线(time-density curve，TDC)。并在时间-密度曲线的基础上，测量孤立性肺结节的强化值、结节－动脉强化值比。
结果 恶性肺结节的灌注参数BV值、P值、强化值和结节-动脉强化值比均高于良性结节，有显著性差异(P值均＜0.05),BF值无显著性差异(P＞0.05)。炎性结节的强化值及结节－动脉强化值比与恶性结节无显著性差异( P＞0.05) 。恶性结节、炎性结节、良性结节的TDC 形态不同。
结论 CT 灌注成像技术提供了孤立性肺结节的血流模式的定量信息，可用于鉴别诊断良恶性孤立性肺结节，64层螺旋CT机可以加大注射流率，减少辐射剂量。 |
| Other Abstract | Objective To investigate the value of solitary pulmonary nodules (SPN) perfusion imaging in 64-slice spiral CT .
Methods A total of 35 patients with SPN underwent perfusion scan with 64-slice spiral CT scanner prospectively.The parameters of CT perfusion, including blood volume (BV) , blood flow (BF) , permeability ( P) and time-density curve ( TDC) were analyzed by randomize syngo BODY PCT. On the basis of TDC ,enhancement CT value and SPN-to-aorta enhanced ratio were measured.
Results These parameter values of BV and P in pulmonary malignancy nodules were highter than those in pulmonary benign nodules. The enhancement value and SPN-to aorta enhanced ratio of the malignant was significantly higher than that of benign nodules ( P＜0.05) .BF value was no significant differences statistically(P＞0.05).No significant differences were found in enhancement value and SPN-to-aorta enhanced ratio between malignant and inflammatory nodules. The TDC appeared difference for the malignant , inflammatory and benign nodules(P＞0.05).
Conclusion Perfusion imaging of CT can provide quantitative information about blood flow patterns of SPNs to differentiate the malignant and benign nodules.The 64-slice spiral CT can improve the perfusion imaging which included increasing injection flow rate and reducing the radiation dose. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/223397
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
张晓军. 孤立性肺结节的64层螺旋CT灌注成像技术及其应用价值[D]. 兰州. 兰州大学,2008.
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