兰州大学机构库 >学院待认领
功能性消化不良胃排空及食物分布与症状的关系
Alternative TitleRelationship Between Gastric Emptying and Intragastric Distribution and Dyspepsia Symptoms in Patients with Functional Dyspepsia
刘秋月
Thesis Advisor严祥
2014-05-24
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword功能性消化不良 胃排空 胃内分布 焦虑 抑郁
Abstract目的 通过对比功能性消化不良患者与健康对照组消化不良症状积分及近、远端胃排空情况的不同,以及两组焦虑、抑郁发病情况,探讨功能性消化不良患者不同胃区胃排空及胃内食物分布与症状之间的关系,以及功能性消化不良患者的心理学特征。 方法 依据Rome Ⅲ诊断标准,收集兰州大学第一医院2012年10月至2013年9月消化科门诊功能性消化不良患者73例(FD组),同时收集兰州大学第一医院工作人员、医学生及其他志愿者共27例,作为健康对照组(HC组),对每例受试者消化不良症状(包括上腹部疼痛、上腹部烧灼感、反酸或口苦、餐后饱胀、恶心、嗳气、呕吐、早饱感)进行评分,并采用实时超声检测其各胃区排空情况。同时对73例FD患者和27例HC组进行Zung焦虑自评量表和Zung抑郁自评量表调查评定。 结果 1. 与HC组比较,FD组除呕吐症状外,其余各消化不良症状发生率均明显增高(P<0.05~0.01)。 2. 以HC组各胃区半排空时间的`x±s为标准,FD组近端胃半排空时间(pT1/2)、远端胃半排空时间(dT1/2)、全胃半排空时间(GT1/2)较HC组均明显延长(P<0.05),FD组中近端、远端、全胃排空延迟率均明显高于HC组(P<0.01)。 3. FD组各时间点各胃区面积均比HC组增大,餐后60 min,FD组近端胃、全胃面积明显增大(P<0.01);餐后90 min,FD组近端、远端、全胃面积明显增大(P<0.05)。 4. FD组pT1/2、GT1/2与各症状均无相关性;dT1/2与患者BMI、早饱感症状呈正相关(P<0.05),与其余症状无相关性;GT1/2与年龄呈负相关(P<0.01)。pT1/2与90 min近端胃面积呈正相关(P<0.01);dT1/2与60 min、90 min远端胃面积呈正相关(P<0.01);GT1/2与60 min、90 min全胃面积呈正相关(P<0.01)。 5. 20 min、40 min近端胃面积,40 min全胃面积与上腹部烧灼感呈负相关(P<0.05);20 min、40 min远端胃面积与早饱感症状积分呈负相关(P<0.05)。 6. 依据排空时间分将FD组为排空延迟组及非延迟组,在餐后60 min、90 min,近端、远端、全胃排空延迟组的近端、远端、全胃面积明显高于非延迟组(P<0.05~0.01)。近端、远端、全胃排空延迟组和非延迟组症状总积分以及各症状积分之间无明显差异(P>0.05)。分别对近端、远端、全胃排空延迟与否进行logistic回归分析,仅早饱感与远端胃排空延迟相关(P<0.05) 7. FD组焦虑、抑郁发生率明显高于正常对照组,两组比较差异有统计学意义(P<0.01) 8. FD组焦虑、抑郁积分明显高于正常对照组,两组比较差异有统计学意义(P<0.01) 结论 本研究结果表明,功能性消化不良患者存在胃排空异常,远端胃排空情况与早饱感存在相关性,功能性消化不良患者具有焦虑、抑郁的心理学特征。
Other AbstractObjective:By comparing the differences of gastric emptying on proximal stomach, distal stomach, total stomach and intragastric distribution,as well as the incidence of anxiety and depression between functional dyspepsia patients and healthy controls, studying relationship between the differences and dyspepsia symptoms in patients with functional dyspepsia (FD),and the psychological characteristics of FD. Methods:Based on Rome Ⅲ criteria, we collected patients with FD in Outpatient department of Gastroenterology, the First Hospital of Lanzhou University, from October 2012 to September 2013.Score for each dyspepsia symptom by using a questionnaire, symptoms including abdominal pain, burning , acid regurgitation or bitter sensation in the mouth or throat, bloating in upper abdominal, nausea, belching, vomiting, early satiety). A real-time ultrasonography was performed in 73 cases of FD patients and 27 healthy controls (HC) to examine the emptying of the each stomach area. The Zung self-rating anxiety scale(SAS)and the Zung self-rating depression scale(SDS) were employed to evaluate the anxiety mood and depression mood respectively of 73 FD patientsand 27 healthy controls. Results: 1. As compared with that in HC group, the incidence of dyspepsia symptoms of FD patients were significantly increased except vomiting (P<0.05 ~ 0.01). 2. As compared with that in HC group, the half time of gastric emptying on proximal stomach (pT1/2), half time of gastric emptying on distal stomach (dT1/2) and gastric emptying half-time on total stomach (GT1/2) was prolonged significantly in FD (P<0.05).The delay rate of proximal stomach, distal stomach and total stomach was significantly increased (P<0.01). 3. Each stomach area in FD group was larger than HC group at the five time points. 60 min after the meal, proximal stomach area, total stomach area in FD group were significantly increased (P<0.01).90 min after meal, proximal stomach area, distal stomach area and total stomach area in FD group were significantly increased (P<0.05). 4. In FD patients, pT1 / 2 and GT1 / 2 were not correlated with each symptom, dT1/2 and early satiety, body mass index were related (P<0.05); GT1/2 was negative correlated with age (P<0.05). pT1 / 2 was positively associated with proximal stomach area at 90 min (P <0.01); dT1 / 2 and 60 min, 90 min distal stomach area were positively correlated (P <0.01); GT1 / 2 and 60 min, 90 min total stomach area were positively correlated (P <0.0...
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223414
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
刘秋月. 功能性消化不良胃排空及食物分布与症状的关系[D]. 兰州. 兰州大学,2014.
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