兰州大学机构库 >学院待认领
高原环境对睡眠剥夺大鼠学习记忆的影响及其机制研究
Alternative TitleThe effect of high-altitude environment on cognitive function of rats after sleep deprevation
司江华
Thesis Advisor杨金升
2010-05-19
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword高原环境 睡眠剥夺 学习记忆 Morris水迷宫
Abstract目的:探讨高原环境对睡眠剥夺(sleep deprivation, SD)大鼠学习记忆能力的影响。 方法:采用小平台水环境法(flower pot)建立大鼠SD模型。选用wistar大鼠64只,根据SD时间的不同(0~5 d),随机分为4组,每组又分为可可西里组(K,海拔4767 m)和兰州组(L,海拔1500 m),可可西里组大鼠由兰州用汽车2天内运至可可西里。在相应时间点对各组大鼠行Morris水迷宫测试,观察并记录动物找到并爬上平台的潜伏期、游泳路程及游泳轨迹,SPT测试中记录大鼠120 s内穿越原平台平面的次数。 结果:1 d、3 d和5 d的潜伏期,K高于L(P<0.05);1 d、3 d和5 d的游泳路程,K高于L(P<0.05),5 d差别最明显(P<0.01);1 d、3 d和5 d的穿越平台次数,K小于L(P<0.01)。 结论:睡眠剥夺使大鼠学习记忆能力降低,高原环境暴露可使睡眠剥夺大鼠学习记忆能力进一步降低。
Other AbstractObjective:To instigative the effect of high-altitude environment on cognitive function of Wistar rats in Sleep Deprivation (SD).Methods:SD was induced in Wista rats by employing “flower pot” technique. The 64 rats were randomly divided into four groups according to the time of SD(0-5 d), and every group was also divided into two subgroups: Kekexili group and Lanzhou group. The behaviors of rats were studied in Morris maze test at given time. Record the escape latency, distance exploration, swimming path to find the hidden platform and the times across plot in 120 s. Results: As compared with those of the Lanzhou groups, the escape latency of Kekexili groups increased in 1 d, 3 d and 5 d(P<0.05), and the ability of distance exploration of Kekexili groups prolonged in 1 d, 3 d and 5 d(P<0.05). The difference reached the climax in 5 d(P<0.01).The times across plot decreased in 1 d,3 d and 5 d(P<0.01). Conclusion:High-altitude environment may have significant influence on cognitive function of rats in SD . SD may have significant influence on cognitive function of rats.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223431
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
司江华. 高原环境对睡眠剥夺大鼠学习记忆的影响及其机制研究[D]. 兰州. 兰州大学,2010.
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