兰州大学机构库 >学院待认领
高血压对心脏结构和功能的影响
Alternative TitleChanges of heart structure and function in patients with essential hypertension
乔瑞丽
Thesis Advisor刘永铭
2011-05-25
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword高血压 心脏结构 左室舒张功能 超声心动图 NT-proBNP
Abstract目的 利用超声心动图等方法,全面了解高血压患者心脏结构和左室舒张功能的改变,探讨心脏结构和功能改变的发生、发展规律。方法 高血压组选原发性高血压患者151例,根据高血压病程分为3个亚组即高血压1组(病程≤5年,n=72)、高血压2组(5年<高血压病程≤10年,n=38)和高血压3组(高血压病程>10年,n=41),并选正常对照54例。利用超声心动图测量心脏结构及多种心功能指标,同时测定血浆氨基末端B型脑钠肽前体(NT-proBNP)、血脂、血糖、尿素氮、肌酐、尿酸等生化指标。结果 (1)高血压患者心脏结构变化:与正常组比较,高血压组室间隔厚度(IVSTd)、左室后壁厚度(PWTd)、相对室壁厚度(RWT)、左室质量(LVM)、左室质量分数(LVMi)、左房内径(LAD)、左房容积(LAV)升高(P<0.05或P<0.01);左室内径及其指数(LVIDd、LVIDi)、左室舒张末期容积及其指数(LVEDV、LVEDVi)等无明显差异。亚组分析显示:IVSTd、PWTd、RWT、LVM、LVMi在高血压1组、2组、3组依次升高,有显著差异(P<0.05或P<0.01);LAV、LAVi高血压1组与对照组相比无明显差异,高血压2组有增大趋势,高血压3组高于对照组及高血压1组、2组(P<0.05或P<0.01),LAD有相似改变;LVEDVi高血压1组小于对照组,高血压3组高于高血压1组(P<0.05),而与对照组无明显差异。
Other AbstractObjective To study the changes of heart structure and left ventricular diastolic function in patients with essential hypertension.Methods One hundred and fifty one consecutive patients with primary hypertension were selected as hypertensive group, which was then divided into three subgroups: hypertensive group 1(the duration of hypertension≤5years, n:72), hypertensive group 2(5years<the duration of hypertension≤10years, n:38), and hypertensive group 3(the duration of hypertension≥10years, n:41). Fifty four age and sex-matched healthy people were selected as the controls. Echocardiograms were performed by use of the methods recommended by American Society of Echocardiography and European Association of Echocardiography in 2005 and 2009. Plasma N-terminal B-type brain natriuretic peptide(NT-proBNP), lipids, glucose, urea nitrogen, creatinine and other relevant laboratory indexes were tested.Results (1) Compared with the controls interventricular septal thickness(IVSTd), posterior wall thickness(PWTd), relative wall thickness(RWT), left ventricular mass(LVM) and LVM index(LVMi), left atrial dimension(LAD), left atrial volume (LAV)of hypertensive group were singnificantly increased. IVSTd, PWTd, RWT, LVM, LVMi were increased group by group in those subgroups(P<0.05-<0.01). LAD, LAV, LAV index(LAVi) in hypertensive subgroup 1 have no difference with controls, but increased in hypertensive subgroup 2 and 3(P<0.05-<0.01). Left ventricular end-diastolic volume index(LVEDVi) of hypertensive subgroup1 was less than that of controls, which had no difference with hypertensive subgroup 2 but increased in hypertensive subgroup 3 (P<0.05).
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223451
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
乔瑞丽. 高血压对心脏结构和功能的影响[D]. 兰州. 兰州大学,2011.
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