兰州大学机构库 >学院待认领
高热惊厥和海马硬化关系的临床研究
Alternative TitleA clinical study about the relationship between febrile seizures and hippocampal sclerosis
石蓓
Thesis Advisor王为民
2014-05-27
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword高热惊厥 海马硬化 癫痫 SPECT分子显像 头颅MRI-MRS 长程V-EEG
Abstract目的:探讨热惊厥类型,癫痫病程、发作间期SPECT分子显像、长程脑电图、发作频率和海马硬化的关系,为临床治疗提供依据。 方法:收集热惊厥史的癫痫患者资料,在我院首次就诊时行长程脑电图(8或12小时)、SPECT、3.0头颅MRI-MRS,统计分析结果。 结果:男34例,女17例,平均年龄16.3岁,平均病程8.2年;3.0MRI-MRS提示海马硬化27例,无海马硬化24例;在27例海马硬化者中,病程≥3年21例,病程<3年6例,无海马硬化24例中,病程≥3年19例,病程<3年3例,p>0.05,病程长短与海马硬化关系并非密切;27例海马硬化者中,脑电图异常21例,正常6例;24例无海马硬化中,异常15例,正常9例,p>0.05,表明是否放电不能提示海马硬化;27例海马硬化者中,SPECT异常24例,正常3例;24例无海马硬化者中,SPECT异常12例,正常12例,p<0.05有统计学意义,表明SPECT异常可提示海马硬化; 51例中复杂型热惊厥22例,海马硬化13例,无海马硬化11例,单纯型热惊厥29例,海马硬化14例,无海马硬化15例,p>0.05,提示热惊厥类型和海马硬化之间并无必然联系。 结论:1.海马硬化和癫痫发作的频率、持续时间,热惊厥的发生频率及持续时间有关,而和癫痫发作类型、病程长短、热惊厥类型无关;2. SPECT异常灌注灶可作为预测海马硬化的指标。
Other AbstractObjective: To investigate the relationship between types of febrile seizure, course of disease, interval SPECT molecular imaging, long-term EEG change, frequency of seizures and Hippocampal sclerosis,for providing a new basis for clinical treatment. Methods: All patients were clinically diagnosed as epilepsy (have a history of febrile seizures); when they had got the first treatment in our hospital,they had long-term EEG monitoring (8 or 12 hours), evaluation of interictal SPECT, 3.0T head MRI-MRS examination . Results: 34 males and 17 females, mean age were 16.3 years. mean duration were 8.2 years. seizure types :no HS were 24 cases;27 cases of HS, duration ≥ 3 years were 21 cases, duration <3 years were 6 cases, no HS were 24 cases, duration ≥ 3 years ware 19 cases, disease duration less than 3 years were 3 patients (p> 0.05),revealing the duration not lead HS; 27 cases of HS, EEG abnormalities in 21 cases, 6 cases of normal; 24 cases of non-HS, the EEG abnormalities in 15 cases, 9 cases of normal (p> 0.05), revealing EEG abnormal discharge does not prompt HS; 27 cases of HS, interictal SPECT molecular imaging abnormalities in 24 cases, the normal were 3 cases; 24 cases without HS ,SPECT abnormalities in 12 cases, normal in 12 cases (p <0.05); revealing SPECT abnormalities can suggestive the trend of HS ;in 51 patients, miscellaneous type of FC were 22 cases, including HS 13 cases, 11 cases without HS, simply type of FC were 29 cases, including 14 cases of HS, no person HS15 cases,( p> 0.05) revealing there was no relation between type of FC and HS.. Conclusions:1. Hippocampal sclerosis has the relationship between seizure frequency, duration, febrile frequency and time of duration, not the types of seizures, duration of disease, and the type of febrile convulsions;2. SPECT abnormal perfusion foci can be used to predict hippocampal sclerosis index.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223462
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
石蓓. 高热惊厥和海马硬化关系的临床研究[D]. 兰州. 兰州大学,2014.
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