|Other Abstract||Objective: To investigate the relationship between types of febrile seizure, course of disease, interval SPECT molecular imaging, long-term EEG change, frequency of seizures and Hippocampal sclerosis，for providing a new basis for clinical treatment.
Methods: All patients were clinically diagnosed as epilepsy (have a history of febrile seizures); when they had got the first treatment in our hospital,they had long-term EEG monitoring (8 or 12 hours), evaluation of interictal SPECT, 3.0T head MRI-MRS examination .
Results: 34 males and 17 females, mean age were 16.3 years. mean duration were 8.2 years. seizure types ：no HS were 24 cases;27 cases of HS, duration ≥ 3 years were 21 cases, duration <3 years were 6 cases, no HS were 24 cases, duration ≥ 3 years ware 19 cases, disease duration less than 3 years were 3 patients (p> 0.05)，revealing the duration not lead HS; 27 cases of HS, EEG abnormalities in 21 cases, 6 cases of normal; 24 cases of non-HS, the EEG abnormalities in 15 cases, 9 cases of normal (p> 0.05), revealing EEG abnormal discharge does not prompt HS; 27 cases of HS, interictal SPECT molecular imaging abnormalities in 24 cases, the normal were 3 cases; 24 cases without HS ,SPECT abnormalities in 12 cases, normal in 12 cases (p <0.05); revealing SPECT abnormalities can suggestive the trend of HS ;in 51 patients, miscellaneous type of FC were 22 cases, including HS 13 cases, 11 cases without HS, simply type of FC were 29 cases, including 14 cases of HS, no person HS15 cases,( p> 0.05) revealing there was no relation between type of FC and HS..
Conclusions：1. Hippocampal sclerosis has the relationship between seizure frequency, duration, febrile frequency and time of duration, not the types of seizures, duration of disease, and the type of febrile convulsions;2. SPECT abnormal perfusion foci can be used to predict hippocampal sclerosis index.|