兰州大学机构库 >学院待认领
肝X受体在阻塞性睡眠呼吸暂停低通气综合症的表达及意义
Alternative TitleThe expression and meaning of liver X receptor in obstructive sleep apnea-hypopnea syndrome patients
亓永杰
Thesis Advisor余勤
2009-05-24
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword睡眠呼吸暂停 巨噬细胞 肝X受体 环氧化酶-2 胆固醇脂转运蛋白
Abstract目的 探讨肝X受体(LXR)及其表达基因胆固醇脂转运蛋白(CETP)、环氧化酶-2(COX2)在阻塞性睡眠呼吸暂停低通气综合症(OSAHS)患者中的作用及意义。方法 收集2007年8月至2008年8月43例OSAHS患者和45名正常人晨血经分离培养后得到巨噬细胞,应用RT-PCR凝胶电泳检测法测相关基因表达。 结果 OSAHS患者LXR、COX2、CETP的表达高于对照组 (P<0.05);OSAHS患者LXR、COX2、CETP与其AHI、LSaO2%均具有相关性;OSAHS患者LXR、CETP的表达在轻中重分组间比较存在增强趋势(P<0.05),COX2的表达各分组间没有明显的增强趋势(P>0.05),其中COX2重度与轻度之间(P<0.05)。 结论 OSAHS患者LXR的表达显著增高,并对CETP、COX2起到调节作用。
Other AbstractAbstract Objective To study the liver X receptor(LXR)and the gene expression of cholesterol ester transfer protein(CETP),cyclooxygenase -2(COX2)in obstructive sleep apnea hypopnea syndrome(OSAHS)patients in the role and significance for OSAHS to provide a more favorable diagnosis,based on more accurate.Methods 30 cases of OSAHS patients and 30 normal blood separation morning training after macrophages,the application of RT-PCR gel electrophoresis detection method of gene expression related to the tendency. Results OSAHS patients LXR,COX2,CETP expression of the higher expression(P<0.05);OSAHS patients LXR,COX2,CETP with AHI,LSaO2% relevance; OSAHS patients with LXR,CETP expression at light heavy division exist to strengthen the trend of inter-comparison(P<0.05),COX2 no clear expression to enhance the trend,COX2 between mild and severe(P<0.05). Conclusion OSAHS patients LXR significantly increased the expression of COX2 and CETP and play a regulating role。 Keywords:sleep apnea;macrophages;liver X receptor;cyclooxygenase-2 cholesterol lipid transporter
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Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223488
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
亓永杰. 肝X受体在阻塞性睡眠呼吸暂停低通气综合症的表达及意义[D]. 兰州. 兰州大学,2009.
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