| 肝X受体在阻塞性睡眠呼吸暂停低通气综合症的表达及意义 |
| Alternative Title | The expression and meaning of liver X receptor in obstructive sleep apnea-hypopnea syndrome patients
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| 亓永杰 |
| Thesis Advisor | 余勤
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| 2009-05-24
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | 睡眠呼吸暂停
巨噬细胞
肝X受体
环氧化酶-2
胆固醇脂转运蛋白
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| Abstract | 目的 探讨肝X受体（LXR）及其表达基因胆固醇脂转运蛋白（CETP）、环氧化酶-2（COX2）在阻塞性睡眠呼吸暂停低通气综合症（OSAHS）患者中的作用及意义。方法 收集2007年8月至2008年8月43例OSAHS患者和45名正常人晨血经分离培养后得到巨噬细胞，应用RT-PCR凝胶电泳检测法测相关基因表达。 结果 OSAHS患者LXR、COX2、CETP的表达高于对照组 （P<0.05）；OSAHS患者LXR、COX2、CETP与其AHI、LSaO2%均具有相关性；OSAHS患者LXR、CETP的表达在轻中重分组间比较存在增强趋势（P<0.05），COX2的表达各分组间没有明显的增强趋势（P>0.05），其中COX2重度与轻度之间（P<0.05）。 结论 OSAHS患者LXR的表达显著增高，并对CETP、COX2起到调节作用。 |
| Other Abstract | Abstract Objective To study the liver X receptor（LXR）and the gene expression of cholesterol ester transfer protein（CETP），cyclooxygenase -2（COX2）in obstructive sleep apnea hypopnea syndrome（OSAHS）patients in the role and significance for OSAHS to provide a more favorable diagnosis，based on more accurate.Methods 30 cases of OSAHS patients and 30 normal blood separation morning training after macrophages，the application of RT-PCR gel electrophoresis detection method of gene expression related to the tendency. Results OSAHS patients LXR，COX2，CETP expression of the higher expression（P<0.05）；OSAHS patients LXR，COX2，CETP with AHI，LSaO2% relevance; OSAHS patients with LXR，CETP expression at light heavy division exist to strengthen the trend of inter-comparison（P<0.05），COX2 no clear expression to enhance the trend，COX2 between mild and severe（P<0.05）. Conclusion OSAHS patients LXR significantly increased the expression of COX2 and CETP and play a regulating role。
Keywords：sleep apnea；macrophages；liver X receptor；cyclooxygenase-2 cholesterol lipid transporter |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/223488
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
亓永杰. 肝X受体在阻塞性睡眠呼吸暂停低通气综合症的表达及意义[D]. 兰州. 兰州大学,2009.
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