兰州大学机构库 >学院待认领
甘肃东乡族RBP4基因多态性与2型糖尿病的相关性分析
Alternative TitleStudy on Association between RBP4 Gene Polymorphisms and Type 2 Diabetes mellitus in Dongxiang People
高静媛
Thesis Advisor刘静 ; 谢小冬
2008-05-27
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
KeywordRBP4基因 DHPLC 单核苷酸多态性 2型糖尿病 连锁不平衡
Abstract目的:  初步探讨视黄醇(维生素A)结合蛋白(RBP4,retinal binding protein 4)基因rs17484721和rs36035572多态性位点的联合变异与甘肃东乡族人群2型糖尿病及胰岛素抵抗的关系。 结论: 甘肃东乡族2型糖尿病患者存在一定程度的向心性肥胖且与胰岛素抵抗、高血压及脂质代谢紊乱密切相关。RBP4基因rs17484721和rs36035572位点单核苷酸多态性与2型糖尿病的易感性相关,并与研究对象的血脂代谢相关。两位点组成的单体型T/T-I/I与2型糖尿病的易感性相关。
Other AbstractObjective Serum retinal binding protein 4(RBP4) was recently described as a new liver- and adipocyte- derived signal that may contribute to Type 2 diabetes mellitus (T2DM) and insulin resistance. To examine this further, two single nucleotide polymorphisms (SNPs) of RBP4 were genetically surveyed in Dongxiang people, who as a group are suffering from a gradual increase in diabetes. Conclusions The data indicates that the variations of RBP4 gene may contribute to susceptibility to T2DM in Dongxiang People.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223518
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
高静媛. 甘肃东乡族RBP4基因多态性与2型糖尿病的相关性分析[D]. 兰州. 兰州大学,2008.
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