兰州大学机构库 >学院待认领
甘氨双唑钠联合放疗治疗鼻咽癌的Meta分析
Alternative TitleA Meta-analysis of metronidazole amino acidum natrium combined with radiotherapy for nasopharyngeal carcinoma
桂岩
Thesis Advisor张小兵
2014-06-06
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword甘氨双唑钠 鼻咽癌 放射治疗 增敏剂 随机对照试验 Meta分析
Abstract目的: 评价甘氨双唑钠(Metronidazole amino acidum natrium,CMNa) 作为放疗增敏剂治疗鼻咽癌的疗效与安全性。 方法: 利用计算机检索Cochrane Library、PubMed、EMbase、中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、中国科技期刊数据库(VIP)和万方数字化期刊全文数据库,同时配合其他检索,收集甘氨双唑钠联合放疗治疗鼻咽癌的随机对照试验(randomized controlled trial,RCT)。按纳入排除标准筛选文献、提取资料和质量评价后,利用RevMan 5.1软件进行Meta分析。 结果: 共纳入16个RCT,经Meta分析显示:在近期疗效方面,甘氨双唑钠联合放疗对比单纯放疗治疗鼻咽癌患者的原发灶、颈部淋巴结转移灶和原发灶复发,差异均具有统计学意义(OR=3.14,95% CI:2.15~4.61,P﹤0. 00001),(OR=2.48,95% CI:1. 60~3.83,P﹤0. 0001)和(OR=3.44,95% CI:1. 72~6.84,P=0. 0004);在鼻咽癌患者的1,3,5年生存率方面,甘氨双唑钠联合放疗疗法对比单纯放疗疗法,差异也具有统计学意义(OR=4.94,95% CI:2.41~10.15,P﹤0. 0001),(OR=2.42,95% CI:1. 31~4.50,P=0. 005)和(OR=2.04,95% CI:1.1 7~3.55,P=0. 01);在恶心呕吐、白细胞降低、影响肝脏功能等毒副反应方面,两组比较差异均无统计学意义(P>0.05)。 结论: 甘氨双唑钠作为放疗增敏剂治疗鼻咽癌,可以改善患者的近期疗效和生存率,并不增加放疗的毒副作用,在临床上具有一定的应用价值。
Other AbstractObjective: To explore the clinical effect and safety of metronidazole amino acidum natrium (CMNa)combined with radiotherapy for nasopharyngeal carcinoma. Methods: Randomized controlled trials (RCTs) were searched from specialized trials registered in the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP and Wan Fang Databases by computer. We also searched the published and unpublished dates by other way, and made quality assessment of qualified RCTs assessed by the exclusion and inclusion criteria. The meta-analysis was conducted by RevMan 5.1 software. Results: A total of 16 RCTs were included. The total effective rate of received CMNa combined with radiotherapy was higher than the received radiotherapy alone for local carcinoma, neck metastatic site and local recurrent nasopharyngeal carcinoma(OR=3.14,95% CI:2.15~4.61,P﹤0. 00001),(OR=2.48,95% CI:1. 60~3.83,P﹤0. 0001) and(OR=3.44,95% CI:1. 72~6.84,P=0. 0004);The significant difference were found in the 1, 3, 5-year survival rates(OR=4.94,95% CI:2.41~10.15,P﹤0. 0001),(OR=2.42,95% CI:1. 31~4.50,P=0. 005) and(OR=2.04,95% CI:1.1 7~3.55,P=0. 01); There was no statistical difference between these two groups of the main toxicities (P>0.05). Conclusion: The CMNa combined with radiotherapy has beneficial effects in treatment of nasopharyngeal carcinoma and less toxicity, so it is worth referring and applying in clinic. Key words: Metronidazole amino acidum natrium, Nasopharyngeal carcinoma, Radiotherapy, Radiosensitizer, Randomized controlled trial, Meta-analysis
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223535
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
桂岩. 甘氨双唑钠联合放疗治疗鼻咽癌的Meta分析[D]. 兰州. 兰州大学,2014.
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